{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T15:25:20Z","timestamp":1792337120392,"version":"4.4.0"},"reference-count":28,"publisher":"BMJ","issue":"1","funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["MSTP T32 GM152316-01"],"award-info":[{"award-number":["MSTP T32 GM152316-01"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,12,13]]},"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>An otherwise healthy young adult male with known glucose-6-phosphate dehydrogenase (G6PD) deficiency presented with severe rhabdomyolysis following routine exercise in the absence of haemolytic anaemia. While G6PD deficiency classically presents with oxidative stress-induced haemolysis, usually reported in the context of infection, medications or toxins, rhabdomyolysis is a rare and atypical manifestation. In this case, no clear precipitating factor for rhabdomyolysis was identified, and the patient did not develop haemolysis. Work up ruled out typical causes of acquired rhabdomyolysis. This presentation highlights the potential for G6PD deficiency to contribute to muscle injury even in the absence of haemolysis and suggests that G6PD deficiency should be considered in the differential diagnosis of atraumatic rhabdomyolysis of unclear aetiology. The patient was treated with intravenous fluids and close monitoring, showed clinical improvement and was discharged in stable condition.<\/jats:p>","DOI":"10.1136\/bcr-2025-268644","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T17:35:10Z","timestamp":1767720910000},"page":"e268644","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Severe rhabdomyolysis as a likely isolated presentation of glucose-6-phosphate dehydrogenase (G6PD) deficiency"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5272-7170","authenticated-orcid":false,"given":"Cynthia Y","family":"Tang","sequence":"first","affiliation":[{"name":"School of Medicine, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimma","family":"Osipov","sequence":"additional","affiliation":[{"name":"Hospital Medicine, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisar","family":"Asmi","sequence":"additional","affiliation":[{"name":"Hospital Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"2026010609350722000_19.1.e268644.1","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2025.1593728","article-title":"Global, regional, and national burden of glucose-6-phosphate dehydrogenase (G6PD) deficiency from 1990 to 2021: a systematic analysis of the global burden of disease study 2021","volume":"16","author":"Yu","year":"2025","journal-title":"Front Genet"},{"key":"2026010609350722000_19.1.e268644.2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00721.2012"},{"key":"2026010609350722000_19.1.e268644.3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3389\/fimmu.2024.1393213","article-title":"The global role of G6PD in infection and immunity","volume":"15","author":"Shah","year":"2024","journal-title":"Front Immunol"},{"key":"2026010609350722000_19.1.e268644.4","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.3390\/cells11193041","article-title":"Glucose 6-P Dehydrogenase\u2014An Antioxidant Enzyme with Regulatory Functions in Skeletal Muscle during Exercise","volume":"11","author":"Garc\u00eda-Dom\u00ednguez","year":"2022","journal-title":"Cells"},{"key":"2026010609350722000_19.1.e268644.5","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(94)90008-6"},{"key":"2026010609350722000_19.1.e268644.6","first-page":"1277","article-title":"Diagnosis and management of G6PD deficiency","volume":"72","author":"Frank","year":"2005","journal-title":"Am Fam Physician"},{"key":"2026010609350722000_19.1.e268644.7","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp160961"},{"key":"2026010609350722000_19.1.e268644.8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/FPC.0000000000000456","article-title":"Incorporating G6PD genotyping to identify patients with G6PD deficiency","volume":"32","author":"Morris","year":"2022","journal-title":"Pharmacogenet Genomics"},{"key":"2026010609350722000_19.1.e268644.9","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.23.291224"},{"key":"2026010609350722000_19.1.e268644.10","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1002\/jcsm.12792","article-title":"Glucose 6-P dehydrogenase delays the onset of frailty by protecting against muscle damage","volume":"12","author":"Arc-Chagnaud","year":"2021","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2026010609350722000_19.1.e268644.11","first-page":"61","article-title":"Rhabdomyolysis: Revisited","volume":"90","author":"Gupta","year":"2021","journal-title":"Ulster Med J"},{"key":"2026010609350722000_19.1.e268644.12","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2021.0111"},{"key":"2026010609350722000_19.1.e268644.13","unstructured":"Yang K . 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