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This case underscores the importance of considering hereditary and acquired C1-INH deficiency in the differential diagnosis of recurrent abdominal pain and bowel oedema despite late onset and lack of concomitant facial or peripheral angioedema. We review the clinical presentation, laboratory evaluation and management of C1-INH deficiency, including the hereditary and acquired forms.<\/jats:p>","DOI":"10.1136\/bcr-2025-268717","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T15:30:20Z","timestamp":1773934220000},"page":"e268717","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Recurrent bowel angioedema in a patient with C1 esterase inhibitor deficiency"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8853-8408","authenticated-orcid":false,"given":"Reem","family":"Matar","sequence":"first","affiliation":[{"name":"Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Volcheck","sequence":"additional","affiliation":[{"name":"Division of Allergic Diseases, Mayo Clinic, Rochester, Minnesota, 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