{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:19:31Z","timestamp":1764249571807,"version":"3.46.0"},"reference-count":13,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,11,7]]},"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                    This case report describes a Japanese woman in her 70s who was initially diagnosed with diffuse panbronchiolitis (DPB) and treated with long-term macrolide therapy. The patient presented with a persistent cough and purulent sputum, and a CT of the chest showed centrilobular opacities. The clinical course, which included the detection of\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    and obstructive impairment, was consistent with DPB. However, the treatment was ineffective, and the opacities worsened over time. Subsequently, 6 years after the initial presentation, yellow nails were observed, leading to a revised diagnosis of yellow nail syndrome (YNS). This noteworthy case, presenting with centrilobular opacities closely resembling DPB, is an important example suggesting that lymphatic dysfunction in YNS may be involved in the formation of centrilobular opacities.\n                  <\/jats:p>","DOI":"10.1136\/bcr-2025-269038","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:15:22Z","timestamp":1764249322000},"page":"e269038","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Diffuse centrilobular nodular opacities in yellow nail syndrome"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7442-0086","authenticated-orcid":false,"given":"Tomoyuki","family":"Ogata","sequence":"first","affiliation":[{"name":"Department of Pulmonology, JA Toride Sogo Iryo Center, Toride, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, JA Toride Medical Center, Toride, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Moriya","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, JA Toride Medical Center, Toride, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, JA Toride Medical Center, Toride, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"2025112705151471000_18.11.e269038.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1964.tb14499.x"},{"key":"2025112705151471000_18.11.e269038.2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.d01-789.x"},{"key":"2025112705151471000_18.11.e269038.3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0137"},{"key":"2025112705151471000_18.11.e269038.4","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.6.9710075"},{"key":"2025112705151471000_18.11.e269038.5","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.6.1459"},{"key":"2025112705151471000_18.11.e269038.6","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2169\/internalmedicine.1466-18","article-title":"Yellow Nail Syndrome Patients with Diffuse Panbronchiolitis-like Pulmonary Manifestation","volume":"58","author":"Imai","year":"2019","journal-title":"Intern Med"},{"key":"2025112705151471000_18.11.e269038.7","article-title":"Yellow nail syndrome with complete triad","volume":"77","author":"Kuwahara","year":"2019","journal-title":"Neth J Med"},{"key":"2025112705151471000_18.11.e269038.8","doi-asserted-by":"crossref","DOI":"10.1186\/s13023-017-0594-4","article-title":"Yellow nail syndrome: a review","volume":"12","author":"Vignes","year":"2017","journal-title":"Orphanet J Rare Dis"},{"key":"2025112705151471000_18.11.e269038.9","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/resp.12357","article-title":"Characteristics of patients with yellow nail syndrome and pleural effusion","volume":"19","author":"Vald\u00e9s","year":"2014","journal-title":"Respirology"},{"key":"2025112705151471000_18.11.e269038.10","doi-asserted-by":"crossref","DOI":"10.1183\/20734735.0163-2021","article-title":"Non-traumatic chylothorax: diagnostic and therapeutic strategies","volume":"18","author":"Ur Rehman","year":"2022","journal-title":"Breathe (Sheff)"},{"key":"2025112705151471000_18.11.e269038.11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/resp.12866","article-title":"Bronchiectasis in yellow nail syndrome","volume":"22","author":"Woodfield","year":"2017","journal-title":"Respirology"},{"key":"2025112705151471000_18.11.e269038.12","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00131805"},{"key":"2025112705151471000_18.11.e269038.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2018.02.011"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-269038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:15:23Z","timestamp":1764249323000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-269038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":13,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,27]]},"published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1136\/bcr-2025-269038"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-269038","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]}}}