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Expert pathology review at a tertiary cancer centre, using comprehensive immunohistochemistry\u2014including paired box gene 8 (PAX8), cancer antigen 125 (CA-125) and hepatocyte nuclear factor 1 beta (HNF1Beta) positivity alongside negative prostatic markers\u2014established a final diagnosis of metastatic clear cell seminal vesicle adenocarcinoma invading the prostate. Despite therapies targeting a checkpoint kinase 2 (CHEK2) mutation (a poly(ADP-ribose) polymerase (PARP inhibitor)), followed by taxanes, platinum-based chemotherapy and radiosurgery for brain metastases, he ultimately succumbed to a stroke linked to his malignancy.<\/jats:p>","DOI":"10.1136\/bcr-2025-269298","type":"journal-article","created":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T13:45:15Z","timestamp":1766324715000},"page":"e269298","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Metastatic clear cell seminal vesicle carcinoma masquerading as high-grade prostate cancer"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3419-2173","authenticated-orcid":false,"given":"Mohamed","family":"M. 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