{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T13:37:18Z","timestamp":1771508238820,"version":"3.50.1"},"reference-count":6,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,2,4]]},"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>A previously healthy woman in her 30s presented with high-grade fever, photophobia and fluctuating consciousness, and was diagnosed with herpes simplex virus type 1\\ encephalitis. Her condition deteriorated, requiring intensive care support for type 1 respiratory failure. During her intensive care unit stay, she was found to have significant left ventricular systolic dysfunction with basal-mid akinesia and apical sparing on echocardiography. Cardiac MRI demonstrated features consistent with stress-induced (Takotsubo) cardiomyopathy. She made a complete neurological and cardiac recovery with supportive care, antiviral therapy and temporary heart-failure therapy. This case highlights the importance of considering cardiac involvement in severe encephalitis and the multidisciplinary management required for rare neuro-cardiac interactions.<\/jats:p>","DOI":"10.1136\/bcr-2025-269447","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:55:12Z","timestamp":1771505712000},"page":"e269447","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Severe herpes simplex virus encephalitis complicated by atypical Takotsubo cardiomyopathy with left ventricular systolic dysfunction"],"prefix":"10.1136","volume":"19","author":[{"given":"Alex","family":"Mathew","sequence":"first","affiliation":[{"name":"North West Anglia NHS Foundation Trust, Peterborough, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosily","family":"Thomas","sequence":"additional","affiliation":[{"name":"North West Anglia NHS Foundation Trust, Peterborough, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9908-9647","authenticated-orcid":false,"given":"Aalekh","family":"Prasad","sequence":"additional","affiliation":[{"name":"North West Anglia NHS Foundation Trust, Peterborough, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"2026021904550763000_19.2.e269447.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2011.11.014"},{"key":"2026021904550763000_19.2.e269447.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1406761"},{"key":"2026021904550763000_19.2.e269447.3","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0007-y"},{"key":"2026021904550763000_19.2.e269447.4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy076"},{"key":"2026021904550763000_19.2.e269447.5","doi-asserted-by":"crossref","first-page":"578138","DOI":"10.1016\/j.jneuroim.2023.578138","article-title":"Takotsubo cardiomyopathy associated with Herpes simplex encephalitis: A case report and literature review","volume":"381","author":"Gharaibeh","year":"2023","journal-title":"J Neuroimmunol"},{"key":"2026021904550763000_19.2.e269447.6","first-page":"932","article-title":"Neurological infections and associated cardiovascular manifestations","volume":"70","author":"Johnson","year":"2020","journal-title":"Clin Infect Dis"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-269447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:55:12Z","timestamp":1771505712000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-269447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":6,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2,19]]},"published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1136\/bcr-2025-269447"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-269447","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]}}}