{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T21:21:22Z","timestamp":1773523282886,"version":"3.50.1"},"reference-count":10,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,12,14]]},"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>Vincristine, a widely used chemotherapeutic agent, may rarely cause optic neuropathy leading to acute vision loss. We describe a patient with T cell lymphoblastic lymphoma who developed sudden bilateral visual impairment following the third cycle of vincristine-based chemotherapy. Extensive evaluation excluded alternative causes, including central nervous system infiltration, opportunistic infections and metabolic disturbances. A diagnosis of vincristine-induced optic neuropathy was made. The patient received high-dose intravenous methylprednisolone along with pyridoxine supplementation, resulting in marked visual recovery within days. This case highlights a potentially reversible but under-recognised complication of vincristine therapy. Early recognition and timely intervention are crucial to prevent permanent visual disability.<\/jats:p>","DOI":"10.1136\/bcr-2025-269563","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:35:23Z","timestamp":1767180923000},"page":"e269563","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Acute vision loss associated with vincristine therapy in T cell lymphoma"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2687-3529","authenticated-orcid":false,"given":"Akash","family":"Paruthi","sequence":"first","affiliation":[{"name":"Department of General Medicine, Sawai Man Singh Medical College and Hospital, Jaipur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Sawai Man Singh Medical College and Hospital, Jaipur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil Kumar","family":"Mahavar","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Sawai Man Singh Medical College and Hospital, Jaipur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajendra Kumar","family":"Kasana","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Sawai Man Singh Medical College and Hospital, Jaipur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveen","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Sawai Man Singh Medical College and Hospital, Jaipur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"2025123106151897000_18.12.e269563.1","first-page":"1549","article-title":"Neurotoxic complications of chemotherapy in patients with cancer: clinical signs and optimal management","volume":"63","author":"Verstappen","year":"2003","journal-title":"Drugs (Abingdon Engl)"},{"key":"2025123106151897000_18.12.e269563.2","first-page":"345","article-title":"Eye complications after hematopoietic stem cell transplantation","volume":"4","author":"Tichelli","year":"2009","journal-title":"Expert Rev Ophthalmol"},{"key":"2025123106151897000_18.12.e269563.3","first-page":"545","article-title":"Management of adults with T-cell lymphoblastic lymphoma","volume":"176","author":"Marks","year":"2017","journal-title":"Br J Haematol"},{"key":"2025123106151897000_18.12.e269563.4","doi-asserted-by":"publisher","DOI":"10.1007\/S12094-010-0474-z"},{"key":"2025123106151897000_18.12.e269563.5","first-page":"533","article-title":"Unilateral optic neuropathy following vincristine chemotherapy","volume":"81","author":"Sanderson","year":"1976","journal-title":"Am J Ophthalmol"},{"key":"2025123106151897000_18.12.e269563.6","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20638"},{"key":"2025123106151897000_18.12.e269563.7","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000024706","article-title":"Bilateral optic neuropathy following vincristine chemotherapy: A case report with description of multimodal imaging findings","volume":"100","author":"Lee","year":"2021","journal-title":"Medicine (Baltimore)"},{"key":"2025123106151897000_18.12.e269563.8","unstructured":"Norton E , Stockman J . Unilateral optic neuropathy post-vincristine in pediatric patients."},{"key":"2025123106151897000_18.12.e269563.9","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.3.432"},{"key":"2025123106151897000_18.12.e269563.10","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.160"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-269563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T14:15:31Z","timestamp":1767190531000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-269563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":10,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12,31]]},"published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1136\/bcr-2025-269563"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-269563","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]}}}