{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T12:56:37Z","timestamp":1781873797196,"version":"3.54.5"},"reference-count":10,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,6,8]]},"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>We report a case of a woman in her 60s who initially presented with typical symptoms of multiple myeloma, including fatigue, muscle cramps, lower back pain, hypercalcaemia, renal impairment and anaemia. Laboratory testing revealed elevated free light chains and M protein bands. Treatment was initiated for a working diagnosis of multiple myeloma. However, bone marrow assessment did not find plasma cells, instead revealing that the malignant clonal cells were of B-cell origin. Treatment was subsequently changed to a chemotherapy regimen for diffuse large B-cell lymphoma. After a suboptimal response, the patient received further treatment with a new regimen, resulting in a good response with no signs of active disease. Over 1 year after completing treatment, the patient remains well.<\/jats:p>","DOI":"10.1136\/bcr-2025-269653","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T12:40:25Z","timestamp":1781872825000},"page":"e269653","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Diffuse large B-cell lymphoma masquerading as multiple myeloma"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7598-9720","authenticated-orcid":false,"given":"Steven","family":"Luo","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5208-1672","authenticated-orcid":false,"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Haematology, Torbay Hospital, Torquay, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"2026061905401663000_19.6.e269653.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2020.05.003"},{"key":"2026061905401663000_19.6.e269653.2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70442-5"},{"key":"2026061905401663000_19.6.e269653.3","article-title":"Primary Bone Lymphoma Masquerading as Multiple Myeloma: Challenges in the Diagnostic Workup of Severe Hypercalcemia","volume":"16","author":"Kahn","year":"2024","journal-title":"Cureus"},{"key":"2026061905401663000_19.6.e269653.4","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2018-229070","article-title":"Hypercalcaemia, renal dysfunction, anaemia and bone lesions (CRAB) do not always represent multiple myeloma: diffuse large B cell lymphoma presenting with CRAB symptoms in a 69-year-old man","volume":"12","author":"Abdullah","year":"2019","journal-title":"BMJ Case Rep"},{"key":"2026061905401663000_19.6.e269653.5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.5045\/br.2015.50.1.61","article-title":"Diffuse large B cell lymphoma with high M protein: an unusual finding","volume":"50","author":"Dang","year":"2015","journal-title":"Blood Res"},{"key":"2026061905401663000_19.6.e269653.6","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-010-0562-4"},{"key":"2026061905401663000_19.6.e269653.7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.hgmx.2016.05.014","article-title":"Paraneoplastic hypercalcaemia and osteolytic lesions secondary to large B-cell lymphoma: Case report and literature review","volume":"81","author":"Covarrubias-Flores","year":"2018","journal-title":"Revista M\u00e9dica Del Hospital General de M\u00e9xico"},{"key":"2026061905401663000_19.6.e269653.8","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000180856.74572.73"},{"key":"2026061905401663000_19.6.e269653.9","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"2026061905401663000_19.6.e269653.10","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.007799"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-269653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T12:40:26Z","timestamp":1781872826000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-269653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":10,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6,19]]},"published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1136\/bcr-2025-269653"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-269653","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]}}}