{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:50:23Z","timestamp":1782489023680,"version":"3.54.5"},"reference-count":12,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,3,5]]},"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>Paravalvular leak (PVL) refers to the retrograde flow of blood through a channel between an implanted valve prosthesis and native cardiac tissue, due to the absence of an appropriate seal. Most PVLs are haemodynamically non-significant; however, large leaks can present with symptoms of heart failure and\/or haemolysis, with impact on quality of life. In many patients, re-operation is associated with high risk and alternative treatments using transcatheter closure techniques have been applied. We present the case of a septuagenarian male who underwent aortic PVL closure facilitated by use of a guide catheter extension and intravascular ultrasound. This report illustrates that these adjunctive techniques, more commonly used in coronary angioplasty procedures, can be used to enable complex PVL closure.<\/jats:p>","DOI":"10.1136\/bcr-2025-269663","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T15:10:15Z","timestamp":1775229015000},"page":"e269663","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Utility of guide catheter extension and intravascular ultrasound to facilitate transcatheter device closure of aortic paravalvular leak"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0230-8007","authenticated-orcid":false,"given":"Beth","family":"Brailsford","sequence":"first","affiliation":[{"name":"Chesterfield Royal Hospital NHS Foundation Trust, Chesterfield, UK"},{"name":"Nottingham University Hospitals NHS Trust, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6021-5738","authenticated-orcid":false,"given":"Thomas Andrew","family":"Kite","sequence":"additional","affiliation":[{"name":"Cardiology, Nottingham University Hospitals NHS Trust, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6038-2237","authenticated-orcid":false,"given":"William Howard Thornton","family":"Smith","sequence":"additional","affiliation":[{"name":"Cardiology, Nottingham University Hospitals NHS Trust, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"2026062608152366000_19.4.e269663.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00834-2"},{"key":"2026062608152366000_19.4.e269663.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200384"},{"key":"2026062608152366000_19.4.e269663.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.09.014"},{"key":"2026062608152366000_19.4.e269663.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.11.043"},{"key":"2026062608152366000_19.4.e269663.5","first-page":"E250","article-title":"Closure of aortic paravalvular leak under intravascular ultrasound and intracardiac echocardiography guidance","volume":"23","author":"Sharma","year":"2011","journal-title":"J Invasive Cardiol"},{"key":"2026062608152366000_19.4.e269663.6","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s11748-016-0700-x","article-title":"Intravascular ultrasound for transcatheter paravalvular leak closure","volume":"65","author":"Murakami","year":"2017","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"2026062608152366000_19.4.e269663.7","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4103\/1995-705X.159221","article-title":"Percutaneous Closure of an Aortic Prosthetic Paravalvular Leak with Device in a Patient Presenting with Heart Failure","volume":"16","author":"Osken","year":"2015","journal-title":"Heart Views"},{"key":"2026062608152366000_19.4.e269663.8","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11112989","article-title":"Paravalvular Leakages after Surgical Aortic-Valve Replacement and after Transcatheter Aortic-Valve Implantation: Strategies to Increase the Success Rate of Percutaneous Closure","volume":"11","author":"Freixa","year":"2022","journal-title":"J Clin Med"},{"key":"2026062608152366000_19.4.e269663.9","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs347"},{"key":"2026062608152366000_19.4.e269663.10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s12928-012-0099-y","article-title":"IVUS guidance in percutaneous closure of aortic paraprosthetic leak","volume":"27","author":"\u00c1vila","year":"2012","journal-title":"Cardiovasc Interv and Ther"},{"key":"2026062608152366000_19.4.e269663.11","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2147\/VHRM.S210928","article-title":"The role of precise imaging with intravascular ultrasound in coronary and peripheral interventions","volume":"15","author":"Shammas","year":"2019","journal-title":"Vasc Health Risk Manag"},{"key":"2026062608152366000_19.4.e269663.12","unstructured":"Boccuzzi G , De Benedictis M , Presbitero P . Transcatheter closure of aortic perivalvular leak using ivus guidance: rationale and case series. Abstracts of EuroPCR 2015 in collaboration with EuroIntervention, Interventions for structural heart disease 2015; Euro15A-MA035; 2015"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-269663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:15:31Z","timestamp":1782486931000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-269663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4,3]]},"published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1136\/bcr-2025-269663"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-269663","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]}}}