{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:03:40Z","timestamp":1784037820319,"version":"3.55.0"},"reference-count":7,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,6,26]]},"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>Superficial siderosis (SS) is a rare, progressive neurological disorder with the most common symptoms being progressive sensorineural hearing loss, ataxia and myelopathy. We aim to report a rare case of the classical type of SS with early cognitive manifestation.<\/jats:p>\n                  <jats:p>An older lady presented with gradual onset hearing loss for 10 years, a decline in episodic memory, executive functions and visuospatial abilities, along with progressive worsening of ataxia and frequent falls for 2 years. After evaluation, a diagnosis of the classical variant of SS was considered. She was started on amantadine up to 200 mg\/day, deferiprone up to 1000 mg\/day, vitamin E supplementation and donepezil. There was a modest improvement in ataxia and frequency of falls.<\/jats:p>","DOI":"10.1136\/bcr-2025-269874","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:05:19Z","timestamp":1784034319000},"page":"e269874","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Classical superficial siderosis: a rare neuropsychiatric disorder"],"prefix":"10.1136","volume":"19","author":[{"given":"Priyanka","family":"Patankar","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archisha","family":"Kalra","sequence":"additional","affiliation":[{"name":"Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0265-2147","authenticated-orcid":false,"given":"Abhiram","family":"Purohith Narasimhan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind N","family":"Prabhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"2026071406050900000_19.7.e269874.1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2021-003324"},{"key":"2026071406050900000_19.7.e269874.2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24850"},{"key":"2026071406050900000_19.7.e269874.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10548-z"},{"key":"2026071406050900000_19.7.e269874.4","doi-asserted-by":"crossref","first-page":"3000605231198389","DOI":"10.1177\/03000605231198389","article-title":"A case report of superficial siderosis of the central nervous system and literature review","volume":"51","author":"Huang","year":"2023","journal-title":"J Int Med Res"},{"key":"2026071406050900000_19.7.e269874.5","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh487"},{"key":"2026071406050900000_19.7.e269874.6","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.4.491"},{"key":"2026071406050900000_19.7.e269874.7","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/cns.12792","article-title":"Two-year observational study of deferiprone in superficial siderosis","volume":"24","author":"Kessler","year":"2018","journal-title":"CNS Neurosci Ther"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-269874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:05:19Z","timestamp":1784034319000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-269874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":7,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7,14]]},"published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1136\/bcr-2025-269874"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-269874","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]}}}