{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:29:26Z","timestamp":1767806966955,"version":"3.49.0"},"reference-count":5,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,12,24]]},"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Gestational trophoblastic neoplasia (GTN) rarely presents concurrently in mother and infant, with very few cases reported worldwide. We describe an infant who presented with vomiting, lethargy and hepatomegaly. Emergency ultrasound revealed hepatomegaly, and contrast-enhanced CT showed large bilobar hepatic lesions with central necrosis and multiple bilateral pulmonary nodules. Despite supportive care, the infant\u2019s condition deteriorated, resulting in death. Post-mortem liver biopsy confirmed metastatic GTN. Shortly thereafter, the mother developed neurological symptoms; brain MRI revealed a haemorrhagic lesion, and chest CT demonstrated pulmonary metastases. Elevated serum beta-human chorionic gonadotropin (\u03b2-hCG) confirmed metastatic choriocarcinoma. MRI was not performed in the infant due to the rapid clinical decline and the need for prolonged sedation, which posed significant risk. This case highlights the importance of considering GTN in infants with atypical hepatic and pulmonary lesions, especially when there is a recent maternal pregnancy. Early \u03b2-hCG testing and timely imaging can facilitate diagnosis and improve outcomes for both mother and child.<\/jats:p>","DOI":"10.1136\/bcr-2025-270038","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T12:45:44Z","timestamp":1767789944000},"page":"e270038","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Dual presentation of metastatic gestational trophoblastic neoplasia in mother and infant: an infrequent diagnostic challenge"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0631-1191","authenticated-orcid":false,"given":"Susmitha","family":"Senthilmurugan","sequence":"first","affiliation":[{"name":"Radiology, Amrita School of Medicine, Kochi, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpa","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"Radiology, Amrita School of Medicine, Kochi, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"2026010704453628000_19.1.e270038.1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.4274\/jtgga.galenos.2023.2023-5-2","article-title":"Gestational trophoblastic neoplasia with concurrent metastasis to the mother and child: a systematic literature review","volume":"24","author":"Mangla","year":"2023","journal-title":"J Turk Ger Gynecol Assoc"},{"key":"2026010704453628000_19.1.e270038.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.06.073"},{"key":"2026010704453628000_19.1.e270038.3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1055\/s-2007-994102","article-title":"A case of neonatal choriocarcinoma","volume":"14","author":"Kishkurno","year":"1997","journal-title":"Am J Perinatol"},{"key":"2026010704453628000_19.1.e270038.4","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1016\/j.ajog.2013.07.002","article-title":"First confirmation by genotyping of transplacental choriocarcinoma transmission","volume":"209","author":"Bolze","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"2026010704453628000_19.1.e270038.5","doi-asserted-by":"crossref","DOI":"10.1186\/s13256-021-02808-3","article-title":"Choriocarcinoma brain metastasis in a patient in the third trimester: a case report","volume":"15","author":"Shen","year":"2021","journal-title":"J Med Case Rep"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-270038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T12:45:45Z","timestamp":1767789945000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-270038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,7]]},"published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1136\/bcr-2025-270038"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-270038","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}