{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T04:38:02Z","timestamp":1770266282744,"version":"3.49.0"},"reference-count":12,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"unspecified","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,1,10]]},"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>Primary ovarian lymphoma is a rare malignancy, representing &lt;1% of ovarian neoplasms and a small subset of extranodal lymphomas, with diffuse large B-cell lymphoma (DLBCL) being the most frequent subtype. Diagnosis is often delayed because symptoms overlap with more common gynaecological or infectious conditions.<\/jats:p>\n                  <jats:p>We report a woman in her 20s presenting with hoarseness, exertional dyspnoea and low-grade fever. Imaging showed mediastinal lymphadenopathy, and repeated biopsies revealed necrotising granulomatous inflammation without malignancy. Persistent symptoms prompted fluorodeoxyglucose (FDG) positron emission tomography (PET)-CT, which detected a hypermetabolic right adnexal mass; MRI suggested a high-grade neoplasm, and tumour markers were normal. Laparoscopic biopsy confirmed high-grade DLBCL (stage IV, germinal-centre B-cell subtype) with a high Ki-67 index.<\/jats:p>\n                  <jats:p>We report a woman in her 20s presenting with hoarseness, exertional dyspnoea and low-grade fever. Imaging showed mediastinal lymphadenopathy, and repeated biopsies revealed necrotising granulomatous inflammation without malignancy. Persistent symptoms prompted FDG PET-CT, which detected a hypermetabolic right adnexal mass; MRI suggested a high-grade neoplasm, and tumour markers were normal. Laparoscopic biopsy confirmed high-grade DLBCL (stage IV, germinal-centre B-cell subtype) with a high Ki-67 index.<\/jats:p>","DOI":"10.1136\/bcr-2025-270123","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T14:56:23Z","timestamp":1770216983000},"page":"e270123","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Primary ovarian diffuse large B-cell lymphoma"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7565-2437","authenticated-orcid":false,"given":"Parvinder","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Armed Forces Medical College, Pune, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V S","family":"Prakash","sequence":"additional","affiliation":[{"name":"Department of Malignant Disease Treatment Centre (MDTC), Command Hospital Pune, Pune, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3108-5866","authenticated-orcid":false,"given":"Anvesh","family":"Rathore","sequence":"additional","affiliation":[{"name":"Department of Malignant Disease Treatment Centre (MDTC), Command Hospital Pune, Pune, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurjeet Singh","family":"Chowdhary","sequence":"additional","affiliation":[{"name":"Department of Malignant Disease Treatment Centre (MDTC), Command Hospital Pune, Pune, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Saraswat","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Command Hospital Pune, Pune, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"2026020406553199000_19.2.e270123.1","first-page":"220","article-title":"Diffuse large B-cell lymphoma (DLBCL): ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"34","author":"Tilly","year":"2023","journal-title":"Ann Oncol"},{"key":"2026020406553199000_19.2.e270123.2","unstructured":"Fox H , Langley FA . Tumours of the ovary. 2nd edn. Washington, DC: Armed Forces Institute of Pathology, 1968."},{"key":"2026020406553199000_19.2.e270123.3","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199302000-00007"},{"key":"2026020406553199000_19.2.e270123.4","doi-asserted-by":"crossref","first-page":"561","DOI":"10.31083\/j.ejgo.2021.03.2377","article-title":"Primary ovarian non-Hodgkin\u2019s lymphoma: a case series and a review of literature","volume":"42","author":"Xiao","year":"2021","journal-title":"Eur J Gynaecol Oncol"},{"key":"2026020406553199000_19.2.e270123.5","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1089\/jayao.2019.0048","article-title":"Primary Ovarian Diffuse Large B Cell Lymphoma: Report of a Rare Case in a Young Female","volume":"8","author":"Zaidi","year":"2019","journal-title":"J Adolesc Young Adult Oncol"},{"key":"2026020406553199000_19.2.e270123.6","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s13224-021-01467-0","article-title":"Primary unilateral ovarian lymphoma in a young girl","volume":"71","author":"Peddappolla","year":"2021","journal-title":"J Obstet Gynaecol India"},{"key":"2026020406553199000_19.2.e270123.7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.2.1073"},{"key":"2026020406553199000_19.2.e270123.8","first-page":"167","article-title":"PET\/CT in primary extranodal lymphoma: staging and treatment","volume":"105","author":"Cohn","year":"2007","journal-title":"Gynecol Oncol"},{"key":"2026020406553199000_19.2.e270123.9","doi-asserted-by":"crossref","first-page":"23247096231154641","DOI":"10.1177\/23247096231154641","article-title":"Ovarian double-hit DLBCL: case report and review","volume":"11","author":"Urella","year":"2023","journal-title":"J Investig Med High Impact Case Rep"},{"key":"2026020406553199000_19.2.e270123.10","doi-asserted-by":"crossref","first-page":"96","DOI":"10.12659\/AJCR.882997","article-title":"Ovary involvement of diffuse large B-cell lymphoma","volume":"13","author":"Hu","year":"2012","journal-title":"Am J Case Rep"},{"key":"2026020406553199000_19.2.e270123.11","article-title":"Five cases of non-hodgkin B-cell lymphoma of the ovary","volume":"2014","author":"Senol","year":"2014","journal-title":"Case Rep Obstet Gynecol"},{"key":"2026020406553199000_19.2.e270123.12","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s40944-023-00734-4","article-title":"A Rare Case of Primary Ovarian Lymphoma\u2014A Diagnostic Dilemma","volume":"21","author":"Gaurav","year":"2023","journal-title":"Indian J Gynecol Oncolog"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-270123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T14:56:25Z","timestamp":1770216985000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-270123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2,4]]},"published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1136\/bcr-2025-270123"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-270123","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]}}}