{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:59:33Z","timestamp":1781092773675,"version":"3.54.1"},"reference-count":24,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,5,24]]},"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>We present the case of radiation recall dermatitis (RRD) induced by ibrutinib therapy in a patient with a history of breast cancer and non-Hodgkin lymphoma. There is currently only one other reported case of Bruton\u2019s tyrosine kinase (BTK) inhibitor therapy-induced RRD in a patient with breast cancer and chronic lymphocytic leukaemia. This case highlights a potentially under-recognised risk of RRD associated with BTK inhibitors, emphasising the need for further research to clarify its pathophysiology and incidence in this treatment context. A deeper understanding of the dermatological side effects of BTK inhibitors can help providers better anticipate, recognise and manage patient symptoms.<\/jats:p>","DOI":"10.1136\/bcr-2025-270200","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:05:28Z","timestamp":1781089528000},"page":"e270200","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Radiation recall dermatitis following ibrutinib therapy in a patient with breast cancer and non-Hodgkin lymphoma"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7129-3125","authenticated-orcid":false,"given":"Mariana","family":"Restrepo","sequence":"first","affiliation":[{"name":"Department of Breast Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Weltz","sequence":"additional","affiliation":[{"name":"Dubin Breast Center of the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Lamb","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Fasano","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"2026061004050822000_19.6.e270200.1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s40257-020-00535-x","article-title":"Dermatological Toxicities of Bruton\u2019s Tyrosine Kinase Inhibitors","volume":"21","author":"Sibaud","year":"2020","journal-title":"Am J Clin Dermatol"},{"key":"2026061004050822000_19.6.e270200.2","unstructured":"Diverse landscape of dermatologic toxicities from small\u2010molecule inhibitor cancer therapy [Journal of Cutaneous Pathology]. Wiley Online Library; 2022. Available: https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/cup.14145"},{"key":"2026061004050822000_19.6.e270200.3","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009-0090"},{"key":"2026061004050822000_19.6.e270200.4","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1053\/j.seminoncol.2022.04.001","article-title":"Radiation recall dermatitis: A review of the literature","volume":"49","author":"Bhangoo","year":"2022","journal-title":"Semin Oncol"},{"key":"2026061004050822000_19.6.e270200.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(01)00328-0"},{"key":"2026061004050822000_19.6.e270200.6","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1001\/jamadermatol.2024.0124","article-title":"Radiation Recall Dermatitis With Bruton Tyrosine Kinase Inhibitor Therapy","volume":"160","author":"Rajeh","year":"2024","journal-title":"JAMA Dermatol"},{"key":"2026061004050822000_19.6.e270200.7","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/tbj.14212","article-title":"Recurrent radiation recall dermatitis 40 years after radiation therapy for breast cancer","volume":"27","author":"Jamaluddin","year":"2021","journal-title":"Breast J"},{"key":"2026061004050822000_19.6.e270200.8","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.ajog.2021.04.217","article-title":"Inflammatory breast cancer: early recognition and diagnosis is critical","volume":"225","author":"Hester","year":"2021","journal-title":"Am J Obstet Gynecol"},{"key":"2026061004050822000_19.6.e270200.9","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.2909"},{"key":"2026061004050822000_19.6.e270200.10","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)00428-6"},{"key":"2026061004050822000_19.6.e270200.11","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15303"},{"key":"2026061004050822000_19.6.e270200.12","first-page":"123","article-title":"Radiation recall dermatitis after treatment of stage IV breast cancer with nivolumab: a case report","volume":"12","author":"Billena","year":"2020","journal-title":"Immunotherapy (Los Angel)"},{"key":"2026061004050822000_19.6.e270200.13","doi-asserted-by":"crossref","DOI":"10.1111\/srt.13621","article-title":"Reflectance confocal microscopy features of chronic radiodermatitis: A useful tool for presurgical mapping","volume":"30","author":"Rapparini","year":"2024","journal-title":"Skin Res Technol"},{"key":"2026061004050822000_19.6.e270200.14","doi-asserted-by":"crossref","first-page":"103696","DOI":"10.1016\/j.critrevonc.2022.103696","article-title":"Ibrutinib-associated dermatologic toxicities: A systematic review and meta-analysis","volume":"174","author":"Nocco","year":"2022","journal-title":"Crit Rev Oncol Hematol"},{"key":"2026061004050822000_19.6.e270200.15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1400376"},{"key":"2026061004050822000_19.6.e270200.16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s11899-020-00576-3","article-title":"Management of Ibrutinib Toxicities: a Practical Guide","volume":"15","author":"Lasica","year":"2020","journal-title":"Curr Hematol Malig Rep"},{"key":"2026061004050822000_19.6.e270200.17","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.jaad.2019.12.031","article-title":"Cutaneous eruptions from ibrutinib resembling epidermal growth factor receptor inhibitor-induced dermatologic adverse events","volume":"88","author":"Singer","year":"2023","journal-title":"J Am Acad Dermatol"},{"key":"2026061004050822000_19.6.e270200.18","doi-asserted-by":"publisher","DOI":"10.1080\/028418699432653"},{"key":"2026061004050822000_19.6.e270200.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2005.07.008"},{"key":"2026061004050822000_19.6.e270200.20","doi-asserted-by":"crossref","first-page":"e135","DOI":"10.1016\/j.jaad.2013.10.046","article-title":"Severe radiation dermatitis associated with concomitant vemurafenib therapy in a patient with metastatic melanoma","volume":"70","author":"Saco","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"2026061004050822000_19.6.e270200.21","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000078"},{"key":"2026061004050822000_19.6.e270200.22","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-016-0120-y"},{"key":"2026061004050822000_19.6.e270200.23","first-page":"33","article-title":"Radiation recall reaction with docetaxel administration after accelerated partial breast irradiation","volume":"3","author":"Miller","year":"2015","journal-title":"Cancer Treat Commun"},{"key":"2026061004050822000_19.6.e270200.24","doi-asserted-by":"publisher","DOI":"10.1111\/TBJ.13504"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-270200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:05:33Z","timestamp":1781089533000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-270200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6,10]]},"published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1136\/bcr-2025-270200"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-270200","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]}}}