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CT and positron emission tomography CT scans showed shrinkage of the primary cancer but changes consistent with LVV. Granulocyte-colony stimulating factor (G-CSF), felt to be the most likely causative agent, was discontinued and the patient started high dose prednisolone, with a prolonged weaning course. At the 6-week follow-up, there was complete resolution of her LVV on CT and normalisation of CRP. She successfully completed her remaining cycles of chemotherapy without G-CSF, and her presentation did not recur. However, her pancreatic cancer remained inoperable, and she sadly died from cancer progression 18 months later.<\/jats:p>","DOI":"10.1136\/bcr-2025-270353","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T13:20:14Z","timestamp":1776864014000},"page":"e270353","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Large vessel vasculitis post granulocyte-colony stimulating factor (G-CSF) use in a patient undergoing neoadjuvant chemotherapy for pancreatic adenocarcinoma"],"prefix":"10.1136","volume":"19","author":[{"given":"Flora MR","family":"Hay","sequence":"first","affiliation":[{"name":"Edinburgh Cancer Centre, NHS Lothian, Western General Hospital, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tze-En","family":"Ding","sequence":"additional","affiliation":[{"name":"Edinburgh Cancer Centre, NHS Lothian, Western General Hospital, Edinburgh, 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