{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T15:10:59Z","timestamp":1778685059970,"version":"3.51.4"},"reference-count":13,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,4,2]]},"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    Urinary bladder paragangliomas (UBPGLs) are rare neuroendocrine tumours, comprising &lt;0.05% of bladder neoplasms. We report a case of a male in his early 30s presenting with persistent lower abdominal discomfort. Imaging showed a hypervascular extraluminal mass on the posteroinferior aspect of the urinary bladder wall with suspicion of a soft tissue tumour likely paraganglioma (PGL). His biochemical markers were within normal limits. The patient underwent open partial cystectomy without complications. Histopathology confirmed PGL with classic zellballen architecture and immunohistochemistry was positive for synaptophysin and chromogranin A. Hence, diagnosis of non-functional UBPGL was confirmed. Genetic testing revealed a pathogenic\n                    <jats:italic>SDHB<\/jats:italic>\n                    mutation (c.550dup) associated with increased metastatic risk. Postoperative recovery was uneventful and follow-up 68Ga-DOTATOC PET-CT showed no evidence of recurrence or metastasis. This case highlights the importance of integrating imaging, histopathology and genetic analysis for management of non-functional UBPGLs and long-term surveillance of this rare entity.\n                  <\/jats:p>","DOI":"10.1136\/bcr-2025-270375","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:20:41Z","timestamp":1778682041000},"page":"e270375","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Paraganglioma of the urinary bladder with a novel variant of\n                    <i>SDHB<\/i>\n                    mutation"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5184-3525","authenticated-orcid":false,"given":"Zahid Aslam","family":"Shivani","sequence":"first","affiliation":[{"name":"Urology, K S Hegde Medical Academy, Mangaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajeev Thekke","family":"Puthalath","sequence":"additional","affiliation":[{"name":"Urology, K S Hegde Medical Academy, Mangaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"2026051307201069000_19.5.e270375.1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.11.5210"},{"key":"2026051307201069000_19.5.e270375.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1806651"},{"key":"2026051307201069000_19.5.e270375.3","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.urolonc.2017.02.006","article-title":"Genitourinary paraganglioma: Demographic, pathologic, and clinical characteristics in the surveillance, epidemiology, and end results database (2000-2012)","volume":"35","author":"Purnell","year":"2017","journal-title":"Urol Oncol"},{"key":"2026051307201069000_19.5.e270375.4","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2490-13-22","article-title":"Pheochromocytoma of the urinary bladder: a systematic review of the contemporary literature","volume":"13","author":"Beilan","year":"2013","journal-title":"BMC Urol"},{"key":"2026051307201069000_19.5.e270375.5","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00345-021-03851-x","article-title":"Differences in clinical presentation and management between pre- and postsurgical diagnoses of urinary bladder paraganglioma: is there clinical relevance? A systematic review","volume":"40","author":"Li","year":"2022","journal-title":"World J Urol"},{"key":"2026051307201069000_19.5.e270375.6","doi-asserted-by":"crossref","first-page":"671","DOI":"10.5858\/arpa.2016-0403-OA","article-title":"Clinicopathologic Characteristics and Mutational Status of Succinate Dehydrogenase Genes in Paraganglioma of the Urinary Bladder: A Multi-Institutional Korean Study","volume":"141","author":"Park","year":"2017","journal-title":"Arch Pathol Lab Med"},{"key":"2026051307201069000_19.5.e270375.7","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1210\/clinem\/dgac427","article-title":"Presentation, Management, and Outcomes of Urinary Bladder Paraganglioma: Results From a Multicenter Study","volume":"107","author":"Yu","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"2026051307201069000_19.5.e270375.8","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1121397","article-title":"SDHB immunohistochemistry for prognosis of pheochromocytoma and paraganglioma: A retrospective and prospective analysis","volume":"14","author":"Su","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026051307201069000_19.5.e270375.9","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5454.848"},{"key":"2026051307201069000_19.5.e270375.10","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1301302"},{"key":"2026051307201069000_19.5.e270375.11","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41574-023-00926-0","article-title":"Management of phaeochromocytoma and paraganglioma in patients with germline SDHB pathogenic variants: an international expert Consensus statement","volume":"20","author":"Ta\u00efeb","year":"2024","journal-title":"Nat Rev Endocrinol"},{"key":"2026051307201069000_19.5.e270375.12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1498"},{"key":"2026051307201069000_19.5.e270375.13","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-021-00492-3"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-270375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:20:42Z","timestamp":1778682042000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-270375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":13,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5,13]]},"published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1136\/bcr-2025-270375"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-270375","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}