{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:35:19Z","timestamp":1792683319296,"version":"4.5.0"},"reference-count":14,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"unspecified","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,3,10]]},"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia (XMEN) disease is due to an inherited defect in immunity from loss-of-function mutations in the magnesium transporter 1 gene (\n                    <jats:italic>MAGT1<\/jats:italic>\n                    ). Patients can present as adults with XMEN disease from a delayed diagnosis or lack of genetic diagnosis. Allogeneic stem-cell transplantation is curative in XMEN disease, but the mortality is high, especially in adults. Defective N-glycosylation of platelet glycoproteins impairs platelet aggregation and risks fatal mucosal haemorrhage (such as posterior epistaxis with airway obstruction and haemorrhagic shock requiring intubation) early during post-transplant aplasia. Maintaining a platelet level of at least 30\u00d710\n                    <jats:sup>9<\/jats:sup>\n                    \/L until engraftment could avoid life-threatening haemorrhage. This is the first report of a successful second allogeneic stem-cell transplant in XMEN disease. Allogeneic stem-cell transplant in adults with XMEN disease should be considered as a curative option in patients with suitable donors.\n                  <\/jats:p>","DOI":"10.1136\/bcr-2025-270597","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T16:10:18Z","timestamp":1774282218000},"page":"e270597","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Second allogeneic stem cell transplantation for XMEN disease"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2804-2531","authenticated-orcid":false,"given":"Baldeep","family":"Wirk","sequence":"first","affiliation":[{"name":"Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, Virginia, 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High-Risk MRD-Negative AML After HSCT: An Open-Label, Multicenter, Randomized Controlled Trial","volume":"38","author":"Gao","year":"2020","journal-title":"J Clin Oncol"},{"key":"2026032309100841000_19.3.e270597.10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaad.2022.06.222","article-title":"33904 Early onset Merkel cell carcinoma in patients with XMEN disease","volume":"87","author":"Mohsin","year":"2022","journal-title":"J Am Acad Dermatol"},{"key":"2026032309100841000_19.3.e270597.11","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1001\/jamadermatol.2023.5362","article-title":"Genetic Risk Factors for Early-Onset Merkel Cell Carcinoma","volume":"160","author":"Mohsin","year":"2024","journal-title":"JAMA Dermatol"},{"key":"2026032309100841000_19.3.e270597.12","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/ijd.15759","article-title":"Merkel cell carcinoma: treatment and outcomes over a 10-year period at a high-volume academic 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