{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:52:40Z","timestamp":1791305560327,"version":"4.3.1"},"reference-count":33,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,9,4]]},"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>Lance-Adams syndrome (LAS) is a rare condition described as chronic intentional myoclonus following prolonged hypoxia. With limited cases of the condition, no standardised diagnostic criteria, and features overlapping acute myoclonus status epilepticus (MSE), diagnosis and management are challenging.<\/jats:p>\n                  <jats:p>Our case is a man in his 20s, who was admitted to the intensive care unit following two in-hospital cardiac arrests. He consequently developed persistent generalised myoclonic seizures despite multiple antiepileptics and sedation. CT, MRI and electroencephalogram (EEG) ruled out a diagnosis of MSE, making LAS more likely. Ketamine was ultimately required to terminate the generalised myoclonic seizures after which antiepileptic drugs were optimised to reduce residual intention myoclonus.<\/jats:p>\n                  <jats:p>This report highlights key features prompting the clinical suspicion of LAS in a patient who has no significant evidence of brain injury, preserved consciousness with continued severe generalised myoclonus and outlines pharmacological and neurophysiological management.<\/jats:p>","DOI":"10.1136\/bcr-2025-270605","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:05:10Z","timestamp":1791302710000},"page":"e270605","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic posthypoxic myoclonus: Lance-Adams syndrome"],"prefix":"10.1136","volume":"19","author":[{"given":"Emily","family":"Dean","sequence":"first","affiliation":[{"name":"Intensive Care, Airedale General Hospital, Keighley, UK"},{"name":"Airedale General Hospital, Keighley, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah","family":"Hussain","sequence":"additional","affiliation":[{"name":"Bradford Royal Infirmary, Bradford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"Garstang","sequence":"additional","affiliation":[{"name":"Airedale General Hospital, Keighley, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Woodcock","sequence":"additional","affiliation":[{"name":"Intensive Care, Airedale General Hospital, Keighley, UK"},{"name":"Airedale General Hospital, Keighley, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Harris","sequence":"additional","affiliation":[{"name":"Intensive Care, Airedale General Hospital, Keighley, UK"},{"name":"Airedale General Hospital, Keighley, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Moriarty","sequence":"additional","affiliation":[{"name":"Airedale General Hospital, Keighley, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4907-6754","authenticated-orcid":false,"given":"Gemma Claire","family":"Lee","sequence":"additional","affiliation":[{"name":"Intensive Care, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK"},{"name":"Medical School, Lancaster University School of Health and Medicine, Lancaster, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"2026100609050845000_19.10.e270605.1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/NRE-2010-0530","article-title":"Hypoxic-ischemic brain injury: addressing the disconnect between pathophysiology and public policy","volume":"26","author":"Arciniegas","year":"2010","journal-title":"NeuroRehabilitation"},{"key":"2026100609050845000_19.10.e270605.2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-948323"},{"key":"2026100609050845000_19.10.e270605.3","doi-asserted-by":"publisher","DOI":"10.4103\/0259-1162.108339"},{"key":"2026100609050845000_19.10.e270605.4","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2011.35.6.939"},{"key":"2026100609050845000_19.10.e270605.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2009.05939.x"},{"key":"2026100609050845000_19.10.e270605.6","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000227183.21314.cd"},{"key":"2026100609050845000_19.10.e270605.7","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410350219"},{"key":"2026100609050845000_19.10.e270605.8","first-page":"41","article-title":"Post-Hypoxic Myoclonus Status following Out-of-Hospital Cardiac Arrest\u2014Does It still Predict a Poor Outcome? 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