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After a partial response to definitive chemoradiotherapy, she underwent two sessions of Alluminox photoimmunotherapy with Akalux (cetuximab\u2013sarotalocan sodium) activated by near-infrared illumination via transoral and transnasal optical diffusers under intraoperative navigation and cone-beam CT. This technique enables selective tumour ablation, induces immunogenic cell death and offers potential synergy with immune checkpoint inhibitors. She achieved complete radiological and pathological remission with minimal toxicity and remains disease-free with preserved oral function at 8 months.<\/jats:p>","DOI":"10.1136\/bcr-2025-270695","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:55:31Z","timestamp":1779195331000},"page":"e270695","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Complete response of unresectable maxillary undifferentiated pleomorphic sarcoma with Alluminox photoimmunotherapy"],"prefix":"10.1136","volume":"19","author":[{"given":"Takahiro","family":"Kanno","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, Izumo, Shimane Prefecture, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Fujioka-Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Oral and 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