{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:20:07Z","timestamp":1787743207658,"version":"build-2784847793"},"reference-count":16,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,8,4]]},"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>Mycosis fungoides (MF) is the most common subtype of cutaneous T cell lymphoma. Oral presentation is both rare and highly variable, often denoting advanced disease stage. A female patient in her 70s was referred regarding painful recurrent palatal ulceration of 6\u2009months\u2019 duration, which was significantly impacting her quality of life. She had known MF treated with oral bexarotene, electron beam therapy and localised radiotherapy. Oral examination revealed two shallow palatal ulcers, and incisional biopsy revealed an atypical stromal and intraepithelial CD3+ T lymphocyte population with a predominance of CD8+ T\u2009cells; PCR revealed T cell receptor gene rearrangements demonstrating a monoclonal population whose profile was identical to that in a recent skin biopsy, indicating oral MF. Unfortunately, the patient succumbed to her disease 7\u2009months after presentation to our unit. This case highlights that oral involvement can develop in MF and can have a significant impact on a patient\u2019s quality of life.<\/jats:p>","DOI":"10.1136\/bcr-2025-270779","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:35:44Z","timestamp":1787740544000},"page":"e270779","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Oral mycosis fungoides"],"prefix":"10.1136","volume":"19","author":[{"given":"David","family":"Byrne","sequence":"first","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, Oral Medicine & Oral Pathology, Dublin Dental University Hospital, Trinity College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Galvin","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, Oral Medicine & Oral Pathology, Dublin Dental University Hospital, Trinity College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Molony","sequence":"additional","affiliation":[{"name":"St James\u2019s Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M","family":"Healy","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, Oral Medicine & Oral Pathology, Dublin Dental University Hospital, Trinity College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"2026082603351415000_19.8.e270779.1","first-page":"1465","article-title":"Interventions for mycosis fungoides","volume":"2020","author":"Valipour","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"2026082603351415000_19.8.e270779.2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-881268"},{"key":"2026082603351415000_19.8.e270779.3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.7665"},{"key":"2026082603351415000_19.8.e270779.4","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/ajh.25577","article-title":"Mycosis fungoides and S\u00e9zary syndrome: 2019 update on diagnosis, risk-stratification, and management","volume":"94","author":"Hristov","year":"2019","journal-title":"Am J Hematol"},{"key":"2026082603351415000_19.8.e270779.5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000530935","article-title":"Oral mycosis fungoides: report of 2 cases and review of the literature","volume":"15","author":"Alexander-Savino","year":"2023","journal-title":"Case Rep Dermatol"},{"key":"2026082603351415000_19.8.e270779.6","unstructured":"Joint Formulary Committee . British National Formulary. London British Medical Association and Royal Pharmaceutical Society of Great Britain; 2023. Available: https:\/\/www.nice.org.uk\/bnf"},{"key":"2026082603351415000_19.8.e270779.7","doi-asserted-by":"crossref","unstructured":"Robinson M , Hunter K , Sloan P , et al . Soames\u2019 & Southam\u2019s Oral Pathology. 5th edn. New York, NY: Oxford University Press, 2018.","DOI":"10.1093\/oso\/9780199697786.001.0001"},{"key":"2026082603351415000_19.8.e270779.8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.oooo.2014.09.009","article-title":"Adverse drug events in the oral cavity","volume":"119","author":"Yuan","year":"2015","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"2026082603351415000_19.8.e270779.9","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/1346-8138.70159","article-title":"Mycosis Fungoides Is a Proliferation of Multiple Mutational Subclones","volume":"53","author":"Honda","year":"2026","journal-title":"J Dermatol"},{"key":"2026082603351415000_19.8.e270779.10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.0630"},{"key":"2026082603351415000_19.8.e270779.11","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197201000-00004"},{"key":"2026082603351415000_19.8.e270779.12","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/s12105-018-0923-5","article-title":"Oral Mycosis Fungoides: A Report of Three Cases and Review of the Literature","volume":"13","author":"Rosebush","year":"2019","journal-title":"Head Neck Pathol"},{"key":"2026082603351415000_19.8.e270779.13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.37549\/ARO1122","article-title":"Mycosis fungoides involving head and neck mucosal sites: Review of the literature","volume":"6","author":"Feldman","year":"2017","journal-title":"Appl Radiat Oncol"},{"key":"2026082603351415000_19.8.e270779.14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41409-023-02122-0","article-title":"Allogeneic stem cell transplant for treatment of mycosis fungoides and Sezary syndrome: a systematic review and meta-analysis","volume":"59","author":"Goyal","year":"2024","journal-title":"Bone Marrow Transplant"},{"key":"2026082603351415000_19.8.e270779.15","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.3390\/cancers17172722","article-title":"Targeted Radiotherapy in Primary Cutaneous Lymphomas: Precision, Efficacy, and Evolving Strategies","volume":"17","author":"Sobolewski","year":"2025","journal-title":"Cancers (Basel)"},{"key":"2026082603351415000_19.8.e270779.16","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00277-015-2503-z","article-title":"A case of oral mycosis fungoides successfully treated by combination of alemtuzumab and chemotherapy","volume":"95","author":"Postorino","year":"2016","journal-title":"Ann Hematol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-270779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:35:46Z","timestamp":1787740546000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-270779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":16,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8,26]]},"published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1136\/bcr-2025-270779"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-270779","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]}}}