{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:06:17Z","timestamp":1784289977171,"version":"3.55.0"},"reference-count":18,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,6,19]]},"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>A female in her early 20s with bilateral congenital aniridia-associated keratopathy (AAK) and progressive limbal stem cell deficiency (LSCD) presented with recurrent epithelial defects in the left eye for which she underwent cadaveric allogeneic simple limbal epithelial transplantation (allo-SLET) with lateral paramedian tarsorrhaphy. Postoperatively, topical and systemic immunosuppression with topical corticosteroids and oral cyclosporine was initiated. The ocular surface stabilised after surgery; however, an episode of epithelial rejection occurred at 4\u2009months which resolved with intensified corticosteroid therapy and intravenous methylprednisolone. Subsequent cataract surgery was performed and the ocular surface remained stable. Best-corrected visual acuity improved from 20\/600 to 20\/160 and remained stable over a 2.5-year follow-up. This case highlights allo-SLET as an effective option for advanced bilateral AAK and the need for long term immunosuppression to prevent episodes of epithelial rejection and recurrence of LSCD.<\/jats:p>","DOI":"10.1136\/bcr-2025-271124","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:40:17Z","timestamp":1784288417000},"page":"e271124","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Allogeneic simple limbal epithelial transplantation (SLET) in aniridia-associated keratopathy"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2407-7787","authenticated-orcid":false,"given":"Shilpa","family":"Tarini","sequence":"first","affiliation":[{"name":"Cornea and Anterior Segment, LV Prasad Eye Institute, GMR Varalakshmi Campus, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4685-9403","authenticated-orcid":false,"given":"Nikita","family":"Das","sequence":"additional","affiliation":[{"name":"Cornea and Anterior Segment, LV Prasad Eye Institute, GMR Varalakshmi Campus, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praful","family":"Rag","sequence":"additional","affiliation":[{"name":"Academy For Eye Care Education, LV Prasad Eye Institute, GMR Varalakshmi Campus, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"2026071704400960000_19.7.e271124.1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jtos.2021.09.001","article-title":"Pathophysiology of aniridia-associated keratopathy: Developmental aspects and unanswered questions","volume":"22","author":"Latta","year":"2021","journal-title":"Ocul Surf"},{"key":"2026071704400960000_19.7.e271124.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01427.x"},{"key":"2026071704400960000_19.7.e271124.3","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.survophthal.2021.02.011","article-title":"Congenital aniridia - 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