{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:08:26Z","timestamp":1790240906717,"version":"4.1.0"},"reference-count":13,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"unspecified","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,8,20]]},"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>We report 18 years of follow-up in a middle-aged Caucasian woman with retinitis pigmentosa (RP) and a non-tractional full-thickness macular hole (FTMH). The case was initially reported after 3 years of observation; this update provides a further 15 years of follow-up and, to our knowledge, represents the longest documented natural history of spontaneous FTMH closure in RP.<\/jats:p>\n                  <jats:p>At presentation, spectral-domain optical coherence tomography (SD-OCT) demonstrated a right-eye FTMH without vitreomacular traction. The patient elected conservative management with serial monitoring. The FTMH subsequently closed spontaneously, leaving a stable lamellar configuration that has remained anatomically unchanged without recurrence for almost two decades. Visual acuity gradually declined, likely due to progressive retinal degeneration and cataract progression, while OCT confirmed long-term foveal stability.<\/jats:p>\n                  <jats:p>This case demonstrates that spontaneous closure of a non-tractional FTMH in RP, although rare, can remain stable in the long term, supporting careful observation in selected patients.<\/jats:p>","DOI":"10.1136\/bcr-2025-271257","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:40:37Z","timestamp":1790239237000},"page":"e271257","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Long-term natural history of spontaneous closure of a full-thickness macular hole in retinitis pigmentosa"],"prefix":"10.1136","volume":"19","author":[{"given":"Claire W","family":"Ruan","sequence":"first","affiliation":[{"name":"Ophthalmology, James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, UK"},{"name":"Ophthalmology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew George","family":"Schneiders","sequence":"additional","affiliation":[{"name":"Ophthalmology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"},{"name":"Ophthalmology, Norfolk and Norwich University Hospital NHS Trust, Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Raja","sequence":"additional","affiliation":[{"name":"Ophthalmology, James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"2026092401401066000_19.9.e271257.1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-304082"},{"key":"2026092401401066000_19.9.e271257.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.01866.x"},{"key":"2026092401401066000_19.9.e271257.3","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31815ec341"},{"key":"2026092401401066000_19.9.e271257.4","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1038\/eye.2008.266","article-title":"Photoreceptor integrity and visual acuity in cystoid macular oedema associated with retinitis pigmentosa","volume":"23","author":"Oishi","year":"2009","journal-title":"Eye (Lond)"},{"key":"2026092401401066000_19.9.e271257.5","doi-asserted-by":"crossref","DOI":"10.1136\/bcr.03.2011.3999","article-title":"Spontaneous resolution of full-thickness macular hole in retinitis pigmentosa","volume":"2011","author":"Raja","year":"2011","journal-title":"BMJ Case Rep"},{"key":"2026092401401066000_19.9.e271257.6","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1988.01060130683026"},{"key":"2026092401401066000_19.9.e271257.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)72781-3"},{"key":"2026092401401066000_19.9.e271257.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.07.042"},{"key":"2026092401401066000_19.9.e271257.9","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1186\/s12886-024-03643-y","article-title":"Pre- and postoperative OCT features and surgical outcomes of advanced retinitis pigmentosa with macular hole: case series and literature review","volume":"24","author":"Song","year":"2024","journal-title":"BMC Ophthalmol"},{"key":"2026092401401066000_19.9.e271257.10","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/eye.2014.344","article-title":"Macular hole in retinitis pigmentosa patients: microincision vitrectomy with polydimethylsiloxane as possible treatment","volume":"29","author":"Vingolo","year":"2015","journal-title":"Eye (Lond)"},{"key":"2026092401401066000_19.9.e271257.11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/ICB.0000000000001491","article-title":"UNILATERAL MACULAR HOLE IN A PATIENT WITH RETINITIS PIGMENTOSA TREATED WITH COVER FLAP TECHNIQUE WITH THE USE OF PLATELET-RICH PLASMA UNDER AIR TAMPONADE","volume":"19","author":"Lo Giudice","year":"2025","journal-title":"Retin Cases Brief Rep"},{"key":"2026092401401066000_19.9.e271257.12","doi-asserted-by":"crossref","DOI":"10.1186\/s12886-021-02082-3","article-title":"Flap technique-assisted surgeries for advanced retinitis pigmentosa complicated with macular hole: a case report and literature review","volume":"21","author":"Lee","year":"2021","journal-title":"BMC Ophthalmol"},{"key":"2026092401401066000_19.9.e271257.13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1752-1947-7-69","article-title":"Unilateral recurrent macular hole in a patient with retinitis pigmentosa: a case report","volume":"7","author":"Garc\u00eda-Fern\u00e1ndez","year":"2013","journal-title":"J Med Case Rep"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-271257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:40:38Z","timestamp":1790239238000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-271257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":13,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9,24]]},"published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1136\/bcr-2025-271257"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-271257","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]}}}