{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:14:11Z","timestamp":1769904851288,"version":"3.49.0"},"reference-count":9,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,1,9]]},"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    We report a paediatric case of acute recurrent pancreatitis (ARP) with persistently elevated salivary-type amylase levels, an uncommon biochemical pattern in ARP. Genetic analysis, focused on pancreatitis-related genes, identified heterozygous mutations in the cystic fibrosis transmembrane conductance regulator (\n                    <jats:italic>CFTR<\/jats:italic>\n                    ) gene (p.Ala72Thr and p.Leu1156Phe). Although the patient showed no typical features or a family history of cystic fibrosis, partial CFTR dysfunction likely led to recurrent pancreatitis with ductal dilatation. Isozyme analysis should be considered when amylase levels remain disproportionately elevated relative to lipase levels, as a predominance of salivary-type amylase may indicate\n                    <jats:italic>CFTR<\/jats:italic>\n                    -related disease and warrant early genetic testing to guide diagnosis and management.\n                  <\/jats:p>","DOI":"10.1136\/bcr-2025-271361","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:45:25Z","timestamp":1769517925000},"page":"e271361","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Elevated salivary amylase levels in paediatric acute recurrent pancreatitis: possible involvement of\n                    <i>CFTR<\/i>\n                    mutations"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7860-0135","authenticated-orcid":false,"given":"Haruka","family":"Honda","sequence":"first","affiliation":[{"name":"Pediatrics, Uwajima City Hospital, Uwajima, Ehime, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Nagatani","sequence":"additional","affiliation":[{"name":"Pediatrics, Uwajima City Hospital, Uwajima, Ehime, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erina","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Clinical Genetic Medicine, Ehime University Hospital, Toon, Ehime, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Pediatrics, Ehime University Hospital, Toon, Ehime, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"2026012704452342000_19.1.e271361.1","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1053\/j.gastro.2018.12.043","article-title":"Pancreatitis in Children","volume":"156","author":"Uc","year":"2019","journal-title":"Gastroenterology"},{"key":"2026012704452342000_19.1.e271361.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199809033391002"},{"key":"2026012704452342000_19.1.e271361.3","unstructured":"Welsh MJ , Tsui LC , Boat TF . Cystic fibrosis. In: Scriver CR , Beaudet AL , Sly WS , eds. The metabolic and molecular bases of inherited disease. New York: McGraw-Hill, 1995."},{"key":"2026012704452342000_19.1.e271361.4","doi-asserted-by":"publisher","DOI":"10.1007\/s535-002-8125-1"},{"key":"2026012704452342000_19.1.e271361.5","article-title":"Acute pancreatitis as the initial presentation of systematic lupus erythematosus","volume":"2014","author":"Jia","year":"2014","journal-title":"Case Rep Gastrointest Med"},{"key":"2026012704452342000_19.1.e271361.6","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1203\/00006450-198011000-00004","article-title":"Serum amylase isoenzymes in cystic fibrosis patients. Evidence for a generalized defect in exocrine gland secretory regulation","volume":"14","author":"Gillard","year":"1980","journal-title":"Pediatr Res"},{"key":"2026012704452342000_19.1.e271361.7","unstructured":"Robert M , et al . Nelson Textbook of Pediatrics. 21st edn. Philadelphia: Elsevier, 2020."},{"key":"2026012704452342000_19.1.e271361.8","doi-asserted-by":"crossref","DOI":"10.1038\/s41439-019-0049-7","article-title":"The CFTR gene variants in Japanese children with idiopathic pancreatitis","volume":"6","author":"Iso","year":"2019","journal-title":"Hum Genome Var"},{"key":"2026012704452342000_19.1.e271361.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2012.05.001"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-271361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:45:27Z","timestamp":1769517927000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-271361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,27]]},"published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1136\/bcr-2025-271361"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-271361","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}