{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T12:14:16Z","timestamp":1788178456034,"version":"build-2803163510"},"reference-count":9,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,8,16]]},"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>A woman in her mid-70s developed uncontrolled intraocular pressure (IOP) in her right eye despite trabeculectomy, Ahmed valve implantation and ongoing topical therapy. Left IOP was normal without treatment. Examination revealed fluffy anterior chamber deposits and vitreous debris. Ultrasound biomicroscopy (UBM) showed diffuse thickening of the iris and ciliary body. Iris biopsy and anterior chamber aspiration confirmed melanoma, and enucleation demonstrated extensive iris and ciliary body involvement with extrascleral extension (stage pT4). This case underscores the diagnostic challenge of lightly pigmented diffuse \u2018tapioca\u2019 iris melanoma and highlights the importance of UBM imaging in evaluating unexplained unilateral glaucoma.<\/jats:p>","DOI":"10.1136\/bcr-2025-271446","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:20:17Z","timestamp":1788175217000},"page":"e271446","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Tapioca iris melanoma masquerading as unilateral glaucoma"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7731-7194","authenticated-orcid":false,"given":"Denis","family":"Nevrov","sequence":"first","affiliation":[{"name":"Ocular Oncology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"D\u2019Arcy","sequence":"additional","affiliation":[{"name":"Ocular Oncology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland"},{"name":"Ophthalmology, St Vincent\u2019s University Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Kennedy","sequence":"additional","affiliation":[{"name":"National Ophthalmic Pathology Laboratory, Royal Victoria Eye and Ear Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel","family":"Horgan","sequence":"additional","affiliation":[{"name":"Ocular Oncology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland"},{"name":"Ophthalmology, St Vincent\u2019s University Hospital, Dublin, Ireland"},{"name":"School of Medicine, University College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"2026083104200947000_19.8.e271446.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2011.10.012"},{"key":"2026083104200947000_19.8.e271446.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01104-1"},{"key":"2026083104200947000_19.8.e271446.3","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/0002-9394(72)91204-4","article-title":"Tapioca melanoma of the iris. 1. Clinical and light microscopy studies","volume":"74","author":"Reese","year":"1972","journal-title":"Am J Ophthalmol"},{"key":"2026083104200947000_19.8.e271446.4","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1444-0938.2008.00344.x","article-title":"Tapioca melanoma of the iris","volume":"92","author":"Pick","year":"2009","journal-title":"Clin Exp Optom"},{"key":"2026083104200947000_19.8.e271446.5","doi-asserted-by":"crossref","DOI":"10.1186\/s12886-021-02236-3","article-title":"Topography and clinical features of iris melanoma","volume":"22","author":"Krohn","year":"2022","journal-title":"BMC Ophthalmol"},{"key":"2026083104200947000_19.8.e271446.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.09.042"},{"key":"2026083104200947000_19.8.e271446.7","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.6.666"},{"key":"2026083104200947000_19.8.e271446.8","unstructured":"Kivel\u00e4 AT , Simpson RE , Grossniklaus HE , et al . Uveal melanoma. In: AJCC Cancer Staging Manual. New York: Springer, 2017: 805\u201317."},{"key":"2026083104200947000_19.8.e271446.9","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.286"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-271446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:20:19Z","timestamp":1788175219000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-271446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":9,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8,31]]},"published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1136\/bcr-2025-271446"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-271446","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]}}}