{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T16:06:58Z","timestamp":1779466018951,"version":"3.53.1"},"reference-count":28,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,5,4]]},"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>Lung cancer during pregnancy is rare, and placental metastases are exceptionally uncommon. Neuroendocrine lung tumours with RET point mutations have scarcely been reported in this setting.<\/jats:p>\n                  <jats:p>An early 40s G6P1031 woman at 33\u2009weeks\u2019 gestation presented with dyspnea and flank pain. Imaging revealed a right lower lobe lung mass with hepatic metastases. Liver biopsy confirmed lung adenocarcinoma with neuroendocrine features and next-generation sequencing identified a RET p.M918T mutation. Following multidisciplinary discussion, labor was induced at 35\u2009weeks with uncomplicated delivery of a healthy infant. Placental pathology demonstrated metastatic carcinoma consistent with pulmonary origin. The patient was treated with selpercatinib, resulting in radiographic response and clearance of circulating RET-mutant DNA. She remains progression-free 10 months into therapy and the infant continues normal development. This is the first reported case of RET p.M918T-mutated neuroendocrine lung cancer with placental metastases diagnosed during pregnancy, highlighting the importance of molecular profiling and multidisciplinary care.<\/jats:p>","DOI":"10.1136\/bcr-2025-271680","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T15:40:13Z","timestamp":1779464413000},"page":"e271680","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["RET-positive neuroendocrine lung cancer in pregnancy with placental metastases"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2724-1432","authenticated-orcid":false,"given":"Subul","family":"Malik","sequence":"first","affiliation":[{"name":"Medicine, University of Miami Leonard M Miller School of Medicine, Miami, Florida, 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