{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:47:37Z","timestamp":1782740857436,"version":"3.54.5"},"reference-count":15,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,6,16]]},"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    Cystic fibrosis (CF) is traditionally regarded as a paediatric disorder, with over 75% of cases diagnosed before the age of 2 years. We describe the case of CF diagnosed in a man in his 70s following investigations prompted by an incidental finding of a pulmonary nodule and bronchiectasis on\u202fimaging. Further multidisciplinary assessment\u202fraised the possibility of CF. The diagnosis was confirmed through elevated sweat chloride levels and CFTR genotyping identifying compound heterozygosity for\n                    <jats:italic>F508del<\/jats:italic>\n                    \u202fand\u202f\n                    <jats:italic>R347H<\/jats:italic>\n                    . This case serves as a timely reminder, particularly for clinicians outside specialist CF services, to consider CF when the constellation of features is suggestive, irrespective of age. It highlights that practice around CF screening in adults with bronchiectasis varies between centres and invites reflection on whether more standardised approaches might help reduce diagnostic delay. For specialist readers, the case further underscores that genotype\u2013phenotype correlations in CF do not always align with expected clinical patterns.\n                  <\/jats:p>","DOI":"10.1136\/bcr-2025-271848","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:10:26Z","timestamp":1782738626000},"page":"e271848","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Cystic fibrosis in a septuagenarian"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9665-2471","authenticated-orcid":false,"given":"Jessie","family":"Johnson","sequence":"first","affiliation":[{"name":"The Shrewsbury and Telford Hospital NHS Trust, Shropshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawaid","family":"Ahmad","sequence":"additional","affiliation":[{"name":"The Shrewsbury and Telford Hospital NHS Trust, Shropshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"2026062906101216000_19.6.e271848.1","doi-asserted-by":"crossref","first-page":"105267","DOI":"10.1016\/j.phrs.2020.105267","article-title":"Cystic fibrosis: Physiopathology and the latest pharmacological treatments","volume":"162","author":"Fonseca","year":"2020","journal-title":"Pharmacol Res"},{"key":"2026062906101216000_19.6.e271848.2","unstructured":"Cystic Fibrosis Foundation . About cystic fibrosis. Bethesda (MD) Cystic Fibrosis Foundation. Available: https:\/\/www.cff.org\/intro-cf\/about-cystic-fibrosis [accessed 23 Apr 2026]"},{"key":"2026062906101216000_19.6.e271848.3","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-304766"},{"key":"2026062906101216000_19.6.e271848.4","first-page":"1341","article-title":"Atypical cystic fibrosis: identification in the primary care setting","volume":"58","author":"Schram","year":"2012","journal-title":"Can Fam Physician"},{"key":"2026062906101216000_19.6.e271848.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2022.07.015"},{"key":"2026062906101216000_19.6.e271848.6","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2018-212463"},{"key":"2026062906101216000_19.6.e271848.7","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0009-9260(99)90847-4","article-title":"Newly diagnosed cystic fibrosis in adults: pattern and distribution of bronchiectasis in 12 cases","volume":"54","author":"Mason","year":"1999","journal-title":"Clin Radiol"},{"key":"2026062906101216000_19.6.e271848.8","unstructured":"McAlindon D . A legacy of changing medicine: cystic fibrosis. New York (NY) Columbia University Irving Medical Center; 2023. Available: https:\/\/www.cuimc.columbia.edu\/news\/legacy-changing-medicine-cystic-fibrosis [accessed 10 Jan 2025]"},{"key":"2026062906101216000_19.6.e271848.9","unstructured":"Royal College of Pathologists of Australasia . The salty kiss: cystic fibrosis screening. PathWay; 2023. Available: https:\/\/www.rcpa.edu.au\/Library\/Publications\/Pathway\/Docs\/The-salty-kiss-cystic-fibrosis-screening [accessed 23 Apr 2026]"},{"key":"2026062906101216000_19.6.e271848.10","doi-asserted-by":"crossref","DOI":"10.1016\/j.anai.2025.08.510","article-title":"Late to diagnose or late to present? Cystic fibrosis in late adulthood: a case report","volume":"135","author":"Farooq","year":"2025","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2026062906101216000_19.6.e271848.11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jcf.2023.12.002","article-title":"Standards for the care of people with cystic fibrosis; establishing and maintaining health","volume":"23","author":"Southern","year":"2024","journal-title":"J Cyst Fibros"},{"key":"2026062906101216000_19.6.e271848.12","unstructured":"Cystic Fibrosis Trust . Standards for the clinical care of children and adults with cystic fibrosis in the UK. London Cystic Fibrosis Trust; 2024. Available: https:\/\/www.cysticfibrosis.org.uk\/sites\/default\/files\/2024-08\/Standards%20for%20the%20clinical%20care%20of%20children%20and%20adults%20with%20cystic%20fibrosis%20in%20the%20UK%202024.pdf [accessed 23 Apr 2026]"},{"key":"2026062906101216000_19.6.e271848.13","unstructured":"Cystic Fibrosis Trust . UK cystic fibrosis registry 2024 annual data report. London Cystic Fibrosis Trust; 2025. Available: https:\/\/www.cysticfibrosis.org.uk\/sites\/default\/files\/2025-12\/2024%20Registry%20Report%20v2.pdf [accessed 28 Apr 2026]"},{"key":"2026062906101216000_19.6.e271848.14","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E14-04-0935"},{"key":"2026062906101216000_19.6.e271848.15","unstructured":"The clinical and functional translation of CFTR (CFTR2). Baltimore (MD) CFTR2. Available: https:\/\/cftr2.org\/ [accessed 23 Apr 2026]"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-271848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:10:40Z","timestamp":1782738640000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-271848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":15,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6,29]]},"published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1136\/bcr-2025-271848"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-271848","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]}}}