{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:02:05Z","timestamp":1784901725037,"version":"3.55.0"},"reference-count":16,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,7,5]]},"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>Nuclear protein in testis (NUT) carcinoma is a rare aggressive cancer typically affecting young adults in midline structures of the head and neck or thorax. A woman in her early 20s presented with non-specific neurological symptoms, including left-sided headache, nausea, vomiting and blurred vision. Blood tests showed slightly elevated infection parameters and imaging revealed an expansile ethmoid mass with orbital and intracranial extension mimicking severe acute ethmoiditis, prompting urgent surgery. Biopsy confirmed NUT carcinoma by immunohistochemistry. The patient underwent radical resection followed by chemo- and radiotherapy. 11 months post-diagnosis, there is no evidence of cancer. Diagnosis of sinonasal NUT carcinoma is complicated by non-specific clinical, radiological and histopathological features, compounded by limited awareness among surgeons, oncologists, radiologists and pathologists. Multidisciplinary management and increased awareness of NUT carcinoma are critical to reduce diagnostic delay and improve prognosis.<\/jats:p>","DOI":"10.1136\/bcr-2026-272003","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:10:20Z","timestamp":1784898620000},"page":"e272003","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Sinonasal NUT carcinoma mimicking acute ethmoiditis"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9702-3930","authenticated-orcid":false,"given":"Hamza Abrar","family":"Mughal","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7119-949X","authenticated-orcid":false,"given":"Mathias M\u00f8rkholm","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willy","family":"Krone","sequence":"additional","affiliation":[{"name":"Department of Radiology, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Darling","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"2026072406100908000_19.7.e272003.1","doi-asserted-by":"crossref","first-page":"1098704","DOI":"10.3389\/fsurg.2023.1098704","article-title":"Sinonasal NUT carcinoma: A retrospective case series from a single institution","volume":"10","author":"Wang","year":"2023","journal-title":"Front Surg"},{"key":"2026072406100908000_19.7.e272003.2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4103\/IJPM.IJPM_373_19","article-title":"Sinonasal NUT midline carcinoma: A new histological entity","volume":"63","author":"Vakani","year":"2020","journal-title":"Indian J Pathol Microbiol"},{"key":"2026072406100908000_19.7.e272003.3","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1002\/hed.28129","article-title":"Sinonasal NUT Carcinoma: A Systematic Review With Pooled Analysis and Report of a Case of Extraordinary Survival","volume":"47","author":"Ahmadian","year":"2025","journal-title":"Head Neck"},{"key":"2026072406100908000_19.7.e272003.4","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.13.12401"},{"key":"2026072406100908000_19.7.e272003.5","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.clinimag.2020.07.025","article-title":"Imaging spectrum of NUT carcinomas","volume":"67","author":"Virarkar","year":"2020","journal-title":"Clin Imaging"},{"key":"2026072406100908000_19.7.e272003.6","doi-asserted-by":"crossref","DOI":"10.3390\/jcm6120116","article-title":"Imaging Characteristics of Malignant Sinonasal Tumors","volume":"6","author":"Kawaguchi","year":"2017","journal-title":"J Clin Med"},{"key":"2026072406100908000_19.7.e272003.7","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s11604-025-01893-4","article-title":"Radiological features of sinonasal NUT (nuclear protein in testis) carcinoma: case series and systematic review","volume":"44","author":"Baba","year":"2026","journal-title":"Jpn J Radiol"},{"key":"2026072406100908000_19.7.e272003.8","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30242"},{"key":"2026072406100908000_19.7.e272003.9","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12727"},{"key":"2026072406100908000_19.7.e272003.10","doi-asserted-by":"publisher","DOI":"10.1177\/0022034518756297"},{"key":"2026072406100908000_19.7.e272003.11","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.1158\/1078-0432.CCR-25-1071","article-title":"Molecular Characterization of NUT Carcinoma: A Report from the NUT Carcinoma Registry","volume":"31","author":"Kim","year":"2025","journal-title":"Clin Cancer Res"},{"key":"2026072406100908000_19.7.e272003.12","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318198d666"},{"key":"2026072406100908000_19.7.e272003.13","article-title":"International guidelines on the diagnosis and treatment of NUT carcinoma","volume":"7","author":"Zhang","year":"2026","journal-title":"Innovation (Camb)"},{"key":"2026072406100908000_19.7.e272003.14","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jtho.2023.12.022","article-title":"Initial Chemotherapy for Locally Advanced and Metastatic NUT Carcinoma","volume":"19","author":"Luo","year":"2024","journal-title":"J Thorac Oncol"},{"key":"2026072406100908000_19.7.e272003.15","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-022-01815-5"},{"key":"2026072406100908000_19.7.e272003.16","unstructured":"The International NUT Carcinoma Registry . NUT Carcinoma Registry. 2025. Available: https:\/\/nc-registry.org [Accessed 1 Dec 2025]."}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2026-272003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:10:21Z","timestamp":1784898621000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2026-272003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":16,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7,24]]},"published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1136\/bcr-2026-272003"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2026-272003","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]}}}