{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:05:02Z","timestamp":1784217902964,"version":"3.55.0"},"reference-count":11,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,6,27]]},"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>A woman in her late 30s presented with a 3\u2009week history of rapidly worsening vision in her right eye. Examination revealed a large amelanotic choroidal mass with subretinal fluid and progressive growth on serial imaging, raising suspicion of malignancy. Systemic workup identified a 14\u2009cm lung mass, which was resected and histologically confirmed as grade II chondrosarcoma. Meanwhile, the choroidal lesion enlarged rapidly to a collar-stud configuration involving the posterior pole, suggesting this to be a chondrosarcoma metastasis. External beam radiotherapy was declined due to lack of histological confirmation and minimal evidence of choroidal metastasis developing from chondrosarcoma in the literature. Given the poor visual prognosis, rapid tumour growth and diagnostic uncertainty, enucleation was performed, confirming metastatic chondrosarcoma. Subsequent imaging demonstrated multifocal skeletal metastases and the patient was placed on palliative care. This case highlights choroidal metastasis as the first manifestation of pulmonary chondrosarcoma and underscores the diagnostic and management challenges in such rare presentations.<\/jats:p>","DOI":"10.1136\/bcr-2026-272136","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:20:25Z","timestamp":1784215225000},"page":"e272136","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Choroidal metastasis as the presenting feature of lung chondrosarcoma"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0866-5683","authenticated-orcid":false,"given":"Camilla","family":"Pagnacco","sequence":"first","affiliation":[{"name":"Sheffield Ocular Oncology Service, Department of Ophthalmology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hardeep Singh","family":"Mudhar","sequence":"additional","affiliation":[{"name":"National Specialist Ophthalmic Pathology Service (NSOPS), Department of Histopathology, Royal Hallamshire Hospital, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hibba","family":"Quhill","sequence":"additional","affiliation":[{"name":"Sheffield Ocular Oncology Service, Department of Ophthalmology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin M","family":"Salvi","sequence":"additional","affiliation":[{"name":"Sheffield Ocular Oncology Service, Department of Ophthalmology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"2026071608201248000_19.7.e272136.1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.H.00416"},{"key":"2026071608201248000_19.7.e272136.2","doi-asserted-by":"publisher","DOI":"10.1097\/BLO.0b013e318059b8c9"},{"key":"2026071608201248000_19.7.e272136.3","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100130345024"},{"key":"2026071608201248000_19.7.e272136.4","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1159\/000494979","article-title":"Chondrosarcoma Metastasis to the Choroid","volume":"5","author":"Kim","year":"2019","journal-title":"Ocul Oncol Pathol"},{"key":"2026071608201248000_19.7.e272136.5","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00417-011-1736-3","article-title":"Choroidal metastasis from chondrosarcoma","volume":"250","author":"Franc\u00e9s-Mu\u00f1oz","year":"2012","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"2026071608201248000_19.7.e272136.6","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.4103\/ijo.IJO_1772_22","article-title":"Choroidal metastasis: Radiation and bevacizumab at presentation","volume":"71","author":"Maheshwari","year":"2023","journal-title":"Indian J Ophthalmol"},{"key":"2026071608201248000_19.7.e272136.7","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.2.159"},{"key":"2026071608201248000_19.7.e272136.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30148-1"},{"key":"2026071608201248000_19.7.e272136.9","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1016\/S0003-4975(01)03462-2","article-title":"Primary mesenchymal chondrosarcoma of the lung","volume":"73","author":"Huang","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"2026071608201248000_19.7.e272136.10","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12072506","article-title":"Chondrosarcoma: A Clinical Review","volume":"12","author":"Gazendam","year":"2023","journal-title":"J Clin Med"},{"key":"2026071608201248000_19.7.e272136.11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4103\/0974-620X.127917","article-title":"Choroidal metastasis from leiomyosarcoma in two cases","volume":"7","author":"Feinstein","year":"2014","journal-title":"Oman J Ophthalmol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2026-272136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:20:27Z","timestamp":1784215227000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2026-272136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":11,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7,16]]},"published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1136\/bcr-2026-272136"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2026-272136","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]}}}