{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T12:56:37Z","timestamp":1781873797147,"version":"3.54.5"},"reference-count":12,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,5,30]]},"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>We describe a case of isolated orbital Rosai-Dorfman disease. Diagnostic uncertainty meant that two biopsies were required to exclude orbital lymphoma and immunoglobulin G4 (IgG4)-related disease. In accordance with histopathological guidelines, we present salient IgG4 parameters. Initial treatment involved oral corticosteroids and an excisional biopsy which led to resolution of symptoms; however, recurrence occurred 4\u2009months later. Avoiding further surgery and in line with the patient\u2019s preference, an intralesional corticosteroid injection was performed. The patient remains symptom-free after 4 years. This case and other cases reviewed here support the consideration for the early use of intralesional corticosteroids, a strategy which may avoid more toxic and resource intensive systemic treatments such as chemotherapy or immunomodulatory therapy.<\/jats:p>","DOI":"10.1136\/bcr-2026-272197","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T12:40:29Z","timestamp":1781872829000},"page":"e272197","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Orbital Rosai-Dorfman disease treated with intralesional corticosteroid injection with 4-year follow-up"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1688-6785","authenticated-orcid":false,"given":"Stephen","family":"Sweetman","sequence":"first","affiliation":[{"name":"Ophthalmology, Swansea Bay University Health Board, Swansea, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garry","family":"Shuttleworth","sequence":"additional","affiliation":[{"name":"Ophthalmology, Swansea Bay University Health Board, Swansea, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Dojcinov","sequence":"additional","affiliation":[{"name":"Ophthalmology, Swansea Bay University Health Board, Swansea, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"2026061905401935000_19.6.e272197.1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-03-839753"},{"key":"2026061905401935000_19.6.e272197.2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10008"},{"key":"2026061905401935000_19.6.e272197.3","first-page":"19","article-title":"Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the 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Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2026-272197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T12:40:30Z","timestamp":1781872830000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2026-272197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":12,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6,19]]},"published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1136\/bcr-2026-272197"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2026-272197","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]}}}