{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:02:07Z","timestamp":1784901727050,"version":"3.55.0"},"reference-count":7,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,7,12]]},"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>Haemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome that may be triggered by infections, including brucellosis. Brucellosis-associated HLH is uncommon in children and may mimic malignancy or severe viral illness.<\/jats:p>\n                  <jats:p>\n                    We report a school-aged boy who presented with prolonged fever, pancytopenia, hepatosplenomegaly, hyperferritinaemia, hypertriglyceridaemia and hypofibrinogenaemia, fulfilling six HLH-2004 diagnostic criteria. Blood cultures confirmed\n                    <jats:italic>Brucella<\/jats:italic>\n                    species infection.\n                  <\/jats:p>\n                  <jats:p>Targeted antimicrobial therapy with gentamicin, doxycycline and rifampicin resulted in complete clinical and haematological recovery without corticosteroids, intravenous immunoglobulin or cytotoxic therapy.<\/jats:p>\n                  <jats:p>This case highlights the importance of recognising infection-triggered HLH in endemic regions and demonstrates that early treatment of the underlying infection may reverse the hyperinflammatory state.<\/jats:p>","DOI":"10.1136\/bcr-2026-272220","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:10:20Z","timestamp":1784898620000},"page":"e272220","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Brucellosis-associated haemophagocytic lymphohistiocytosis in a child"],"prefix":"10.1136","volume":"19","author":[{"given":"Ahmad Zaher","family":"Kour","sequence":"first","affiliation":[{"name":"Pediatric, Bahla Hospital, Bahla, Oman"},{"name":"Government of Oman Ministry of Health, Muscat, Muscat Governorate, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamda","family":"Al Abri","sequence":"additional","affiliation":[{"name":"Pediatric, Oman Medical Speciality Board, Al-Athaiba, Muscat Governorate, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"2026072406101131000_19.7.e272220.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70382-6"},{"key":"2026072406101131000_19.7.e272220.2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"2026072406101131000_19.7.e272220.3","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000780"},{"key":"2026072406101131000_19.7.e272220.4","doi-asserted-by":"crossref","unstructured":"Xu M , Zhang L , Wang J , et al . Brucella-induced haemophagocytic lymphohistiocytosis in a child: case report and literature review. SAGE Open Med Case Rep 2023;11. doi:10.1177\/2050313X231207562","DOI":"10.1177\/2050313X231207562"},{"key":"2026072406101131000_19.7.e272220.5","article-title":"Brucellosis complicated by haemophagocytic lymphohistiocytosis: a case report and literature review","volume":"16","author":"Al Noumani","year":"2024","journal-title":"Cureus"},{"key":"2026072406101131000_19.7.e272220.6","first-page":"1458721","article-title":"Brucella-associated haemophagocytic lymphohistiocytosis: a systematic review of published cases","volume":"12","author":"Jiang","year":"2025","journal-title":"Front Med (Lausanne)"},{"key":"2026072406101131000_19.7.e272220.7","first-page":"4275","article-title":"Brucellosis in children: a review","volume":"13","author":"Khan","year":"2020","journal-title":"Infect Drug Resist"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2026-272220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:10:21Z","timestamp":1784898621000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2026-272220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":7,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7,24]]},"published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1136\/bcr-2026-272220"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2026-272220","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]}}}