{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:51:16Z","timestamp":1782489076390,"version":"3.54.5"},"reference-count":15,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,3,12]]},"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>Chronic pulmonary aspergillosis (CPA) is a slowly progressive fungal infection that commonly complicates underlying structural lung disease and is frequently misdiagnosed in tuberculosis-endemic regions. Invasive forms of CPA can closely mimic lung malignancy.<\/jats:p>\n                  <jats:p>\n                    A man in his late 30s with a history of repeated empirical antitubercular therapy presented with progressive dyspnoea, chronic cough with mucoid sputum, seasonal variation of symptoms and recurrent haemoptysis. Imaging revealed a large right upper lobe mass with mediastinal extension, vascular encasement and complete bronchial obstruction, suggestive of advanced lung cancer. Spirometry showed reversible airflow obstruction, and immunological testing demonstrated markedly elevated total IgE with\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    sensitisation. Flexible bronchoscopy revealed an endobronchial growth occluding the right main bronchus. Histopathology confirmed fungal granulomatous inflammation consistent with\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    . Despite antifungal therapy, the patient developed massive haemoptysis and died.\n                  <\/jats:p>\n                  <jats:p>This case highlights the diagnostic overlap between CPA, tuberculosis and lung cancer, and emphasises that coexisting asthma or allergic Aspergillus disease does not exclude invasive Aspergillus infection.<\/jats:p>","DOI":"10.1136\/bcr-2026-272323","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:05:24Z","timestamp":1775145924000},"page":"e272323","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Invasive chronic pulmonary aspergillosis masquerading as lung malignancy in a patient with asthma and ABPA overlap"],"prefix":"10.1136","volume":"19","author":[{"given":"Javeeria","family":"Shabbir","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, AIIMS Patna, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somesh","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, AIIMS Patna, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisha G","family":"Panicker\u00b2","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, AIIMS Patna, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnan E","family":"Namboothri","sequence":"additional","affiliation":[{"name":"AIIMS Patna, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, AIIMS Patna, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaodam Collin","family":"Singh","sequence":"additional","affiliation":[{"name":"AIIMS Patna, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"2026062608151923000_19.4.e272323.1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00583-2015"},{"key":"2026062608151923000_19.4.e272323.2","first-page":"149","article-title":"Underlying conditions in chronic pulmonary aspergillosis including simple aspergilloma","volume":"30","author":"Smith","year":"2011","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2026062608151923000_19.4.e272323.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2006.02.004"},{"key":"2026062608151923000_19.4.e272323.4","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s13256-021-02721-9","article-title":"Misdiagnosis of chronic pulmonary aspergillosis as pulmonary tuberculosis at a tertiary care center in Uganda: a case series","volume":"15","author":"Oladele","year":"2021","journal-title":"J Med Case Reports"},{"key":"2026062608151923000_19.4.e272323.5","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.6.1988"},{"key":"2026062608151923000_19.4.e272323.6","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.2.310"},{"key":"2026062608151923000_19.4.e272323.7","first-page":"227","article-title":"Allergic bronchopulmonary aspergillosis","volume":"54","author":"Agarwal","year":"2012","journal-title":"Indian J Chest Dis Allied"},{"key":"2026062608151923000_19.4.e272323.8","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.155515"},{"key":"2026062608151923000_19.4.e272323.9","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.11.089441"},{"key":"2026062608151923000_19.4.e272323.10","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0276-3"},{"key":"2026062608151923000_19.4.e272323.11","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00001011"},{"key":"2026062608151923000_19.4.e272323.12","doi-asserted-by":"crossref","DOI":"10.1093\/jscr\/rjaa169","article-title":"Aspergillus-related lung mass masquerading as a lung tumour","volume":"2020","author":"Mohamed","year":"2020","journal-title":"J Surg Case Rep"},{"key":"2026062608151923000_19.4.e272323.13","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw326"},{"key":"2026062608151923000_19.4.e272323.14","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206291"},{"key":"2026062608151923000_19.4.e272323.15","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00053-10"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2026-272323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:21:10Z","timestamp":1782487270000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2026-272323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4,2]]},"published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1136\/bcr-2026-272323"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2026-272323","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]}}}