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Intraoperative frozen section revealed a malignant spindle cell neoplasm, prompting definitive surgical resection during the same anaesthetic event. Final histopathology and molecular analysis confirmed melanoma, with no identifiable cutaneous, mucosal or ocular primary. The patient subsequently received adjuvant immunotherapy and remains disease-free at 24 months. This case highlights the diagnostic challenge of pulmonary melanoma mimicking lung carcinoma and demonstrates how integration of robotic bronchoscopy and robotic surgery can enable rapid diagnosis, definitive management and streamlined care within a single operative session.<\/jats:p>","DOI":"10.1136\/bcr-2026-272596","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:05:20Z","timestamp":1791302720000},"page":"e272596","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Same-day diagnosis and robotic resection of rare primary pulmonary melanoma: a robotic bronchoscopy-guided approach"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5273-6602","authenticated-orcid":false,"given":"Andres","family":"Fontaine-Nicola","sequence":"first","affiliation":[{"name":"Division of Cardiothoracic Surgery, Department of Surgery, University of Illinois Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano Gabriel","family":"Manueli Laos","sequence":"additional","affiliation":[{"name":"Division of General, Minimally Invasive and Robotic Surgery, University of Illinois Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario A","family":"Masrur","sequence":"additional","affiliation":[{"name":"Division of General, Minimally Invasive and Robotic Surgery, University of Illinois Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin L","family":"Kovitz","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"David","sequence":"additional","affiliation":[{"name":"Pathology, University of Illinois Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Abdelhady","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Department of Surgery, University of Illinois Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"2026100609051139000_19.10.e272596.1","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics14040399","article-title":"Robotic-Assisted Bronchoscopy: A Comprehensive Review of System Functions and Analysis of Outcome Data","volume":"14","author":"Prado","year":"2024","journal-title":"Diagnostics (Basel)"},{"key":"2026100609051139000_19.10.e272596.2","unstructured":"Intuitive . How the ion endoluminal system works. Available: https:\/\/www.intuitive.com\/en-gb\/products-and-services\/ion\/how-ion-works [Accessed 22 Jun 2025]."},{"key":"2026100609051139000_19.10.e272596.3","doi-asserted-by":"crossref","DOI":"10.21037\/atm-22-3078","article-title":"Robotic bronchoscopy in diagnosing lung cancer-the evidence, tips and tricks: a clinical practice review","volume":"11","author":"Ho","year":"2023","journal-title":"Ann Transl Med"},{"key":"2026100609051139000_19.10.e272596.4","unstructured":"Scott JF , Gerstenblith MR . Melanoma of unknown primary. In: Scott JF , Gerstenblith MR , eds. Noncutaneous melanoma. 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