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During this time, he underwent surgical aortic valve replacement for severe aortic stenosis with coronary artery bypass grafting. The latter procedure was complicated by an infection. Unexpectedly, post-operative restaging imaging demonstrated complete resolution without further anti-cancer therapy. The patient has remained in complete remission on surveillance alone for more than 6 years. Two years after surgery, he developed a new honeybee venom allergy, suggesting an alteration in immune responsiveness. This case highlights a rare and durable regression of metastatic melanoma temporally associated with major surgery and supports the hypothesis that surgery-associated systemic immune activation may contribute to long-term tumour control.\n                  <\/jats:p>","DOI":"10.1136\/bcr-2026-272670","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T11:15:19Z","timestamp":1781694919000},"page":"e272670","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Complete regression of metastatic melanoma in a patient following open-heart surgery with an infective complication"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0183-2074","authenticated-orcid":false,"given":"Po","family":"Liu","sequence":"first","affiliation":[{"name":"School of Medicine, Adelaide University, Adelaide, South Australia, Australia"},{"name":"Department of Medical Oncology, 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