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Diagnostic evaluation revealed hypoplasia of the vertebral arteries and the left posterior communicating artery, as well as an ocular coloboma, confirmed by ophthalmology. Given that early diagnosis is essential to prevent serious complications, this report emphasises that infants with extensive facial haemangiomas should undergo multidisciplinary screening, including neurology, ophthalmology and cardiology, and vascular imaging to ensure comprehensive management.<\/jats:p>","DOI":"10.1136\/bcr-2026-273029","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T14:00:17Z","timestamp":1787148017000},"page":"e273029","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["PHACE syndrome in an infant: the importance of multidisciplinary screening in extensive facial infantile haemangiomas"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3784-558X","authenticated-orcid":false,"given":"Yuri Igor","family":"Lopez Carrera","sequence":"first","affiliation":[{"name":"Dermatology, Hospital Angeles Puebla, Puebla, Pue, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alondra","family":"Valdez Maya","sequence":"additional","affiliation":[{"name":"Universidad Anahuac Puebla, Puebla, Pue, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Ortiz Farris","sequence":"additional","affiliation":[{"name":"Universidad Anahuac Puebla, Puebla, Pue, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"2026081907001144000_19.8.e273029.1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1186\/s13023-025-03899-7","article-title":"PHACE syndrome: looking backward and forward","volume":"20","author":"Zhang","year":"2025","journal-title":"Orphanet J Rare Dis"},{"key":"2026081907001144000_19.8.e273029.2","article-title":"\u201cFace(s)\u201d of a PHACE(S) Syndrome Patient before and after Therapy: Particular Case Report and Review of Literature","volume":"9","author":"St\u0103nciulescu","year":"2022","journal-title":"Children (Basel)"},{"key":"2026081907001144000_19.8.e273029.3","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1159\/000508187","article-title":"Epidemiology, Clinical Features, and Use of Early Supportive Measures in PHACE Syndrome: A European Multinational Observational Study","volume":"54","author":"Disse","year":"2020","journal-title":"Neuroepidemiology"},{"key":"2026081907001144000_19.8.e273029.4","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1996.03890270083012"},{"key":"2026081907001144000_19.8.e273029.5","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1590\/abd1806-4841.20187693","article-title":"PHACE syndrome: clinical manifestations, diagnostic criteria, and management","volume":"93","author":"Rotter","year":"2018","journal-title":"An Bras Dermatol"},{"key":"2026081907001144000_19.8.e273029.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.07.054"},{"key":"2026081907001144000_19.8.e273029.7","doi-asserted-by":"crossref","first-page":"101152","DOI":"10.1016\/j.spen.2024.101152","article-title":"PHACE syndrome: A review","volume":"51","author":"Keith","year":"2024","journal-title":"Semin Pediatr Neurol"},{"key":"2026081907001144000_19.8.e273029.8","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.1038\/s41598-024-55345-6","article-title":"Numerical flow experiment for assessing predictors for cerebrovascular accidents in patients with PHACES syndrome","volume":"14","author":"Wi\u015bniewski","year":"2024","journal-title":"Sci Rep"},{"key":"2026081907001144000_19.8.e273029.9","doi-asserted-by":"crossref","DOI":"10.1136\/archdischild-2020-318923","article-title":"PHACE syndrome: importance of distinguishing infantile haemangioma from capillary malformation","volume":"105","author":"Sazali","year":"2020","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2026081907001144000_19.8.e273029.10","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2018-3475","article-title":"Clinical Practice Guideline for the Management of Infantile Hemangiomas","volume":"143","author":"Krowchuk","year":"2019","journal-title":"Pediatrics"},{"key":"2026081907001144000_19.8.e273029.11","first-page":"1","article-title":"Gu\u00eda mexicana para el diagn\u00f3stico y el tratamiento del hemangioma infantil","volume":"81","author":"Toledo-Bahena","year":"2024","journal-title":"Bol Med Hosp Infant Mex"},{"key":"2026081907001144000_19.8.e273029.12","doi-asserted-by":"crossref","DOI":"10.1097\/JOVA.0000000000000023","article-title":"Safe Use of Propranolol in a Patient With PHACES Syndrome: A Case Report","volume":"2","author":"Ferreira","year":"2021","journal-title":"Journal of Vascular Anomalies"},{"key":"2026081907001144000_19.8.e273029.13","unstructured":"Consulta de registros sanitarios. 2026. 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