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Completion right hemicolectomy was subsequently undertaken for definitive oncologic management and lymph node staging and revealed no residual carcinoma, with nine negative lymph nodes. Postoperative staging imaging showed no evidence of metastatic disease, and the patient was managed with oncologic surveillance. This case highlights the diagnostic limitation of imaging in differentiating appendiceal mucocele from invasive malignancy and underscores the importance of histopathologic evaluation and appropriate oncologic resection in goblet cell adenocarcinoma.<\/jats:p>","DOI":"10.1136\/bcr-2026-273268","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:55:22Z","timestamp":1780502122000},"page":"e273268","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Appendiceal mucocele on imaging masking invasive goblet cell adenocarcinoma"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4387-9727","authenticated-orcid":false,"given":"Yanina","family":"Nikolaus","sequence":"first","affiliation":[{"name":"Pathology, Marshall University Joan C Edwards School of Medicine, Huntington, West Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"2026060308551435000_19.6.e273268.1","unstructured":"WHO Classification of Tumours Editorial Board . 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