{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:20:41Z","timestamp":1788261641322,"version":"build-2803163510"},"reference-count":11,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,8,20]]},"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    A man in his 20s with recurrent glioma developed rapid-onset trismus and left temporomandibular swelling. Imaging revealed condylar destruction with a mineralised mass. Initial biopsy suggested chondroblastic osteosarcoma; germline testing confirmed Li-Fraumeni syndrome with a pathogenic\n                    <jats:italic>TP53<\/jats:italic>\n                    variant. He underwent segmental resection with temporomandibular joint disarticulation, facial-nerve sacrifice and vascularised free fibular flap reconstruction. The case underscores the need for germline testing in young patients with multiple primary malignancies and adherence to oncological principles despite challenging anatomy.\n                  <\/jats:p>","DOI":"10.1136\/bcr-2026-273397","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:10:11Z","timestamp":1788261011000},"page":"e273397","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Li-Fraumeni syndrome presenting with temporomandibular chondroblastic osteosarcoma following recurrent glioma"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8163-3904","authenticated-orcid":false,"given":"Sujeeth Kumar","family":"Shetty","sequence":"first","affiliation":[{"name":"Oral and Maxillofacial Surgery, JSS Dental College and Hospital, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2908-6290","authenticated-orcid":false,"given":"Sonakshi","family":"Prakash","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgery, JSS Dental College and Hospital, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4302-7054","authenticated-orcid":false,"given":"Devika M","family":"Krishna","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgery, JSS Dental College and Hospital, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"2026090104100580000_19.9.e273397.1","article-title":"Does PTEN gene mutation play any role in Li-Fraumeni syndrome","volume":"30","author":"Akouchekian","year":"2016","journal-title":"Med J Islam Repub Iran"},{"key":"2026090104100580000_19.9.e273397.2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s12672-024-01435-w","article-title":"Current insights and future directions of Li-Fraumeni syndrome","volume":"15","author":"Hosseini","year":"2024","journal-title":"Discov Onc"},{"key":"2026090104100580000_19.9.e273397.3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252111477","article-title":"Li-Fraumeni syndrome: narrative review through a case report","volume":"25","author":"Amador-G\u00f3mez","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026090104100580000_19.9.e273397.4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.5728"},{"key":"2026090104100580000_19.9.e273397.5","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1177\/1947601911413466","article-title":"Li-fraumeni syndrome","volume":"2","author":"Malkin","year":"2011","journal-title":"Genes Cancer"},{"key":"2026090104100580000_19.9.e273397.6","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30248"},{"key":"2026090104100580000_19.9.e273397.7","unstructured":"WHO Classification of Tumours Editorial Board . 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