{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T11:18:57Z","timestamp":1787915937308,"version":"build-2784847793"},"reference-count":12,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,8,20]]},"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>Plasma rich in growth factors (PRGF) has been used as an intraoperative biological adjunct in vitreomacular surgery to support structural repair. We report two cases of macular reactivity following PRGF application in eyes with underlying inflammatory priming. In the first case, a man with a history of intermediate uveitis underwent vitrectomy with fovea-sparing peeling and PRGF application for tractional foveoschisis. Postoperatively, transient contractile macular changes were observed, which regressed spontaneously, and anatomical stability was maintained. In the second case, a woman with rheumatoid arthritis and proliferative vitreoretinopathy underwent repeat surgery with PRGF for a persistent macular hole. One month later, marked macular oedema developed, requiring escalation of anti-inflammatory therapy. These cases raise the possibility that adjunctive PRGF may contribute to postoperative macular reactivity in eyes with underlying inflammatory predisposition, underscoring the need for careful patient selection and close postoperative monitoring.<\/jats:p>","DOI":"10.1136\/bcr-2026-274277","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:55:20Z","timestamp":1787914520000},"page":"e274277","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Macular reactivity following adjunctive PRGF in vitreomacular surgery with inflammatory predisposition"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2074-9760","authenticated-orcid":false,"given":"Bruno","family":"Guerreiro Dias","sequence":"first","affiliation":[{"name":"Ophthalmology, Hospital de Santa Maria - Unidade Local de Sa\u00fade de Santa Maria, Lisbon, Portugal"},{"name":"Cl\u00ednica Universit\u00e1ria de Oftalmologia, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3842-2466","authenticated-orcid":false,"given":"Carlos","family":"Marques-Neves","sequence":"additional","affiliation":[{"name":"Ophthalmology, Hospital de Santa Maria - Unidade Local de Sa\u00fade de Santa Maria, Lisbon, Portugal"},{"name":"Cl\u00ednica Universit\u00e1ria de Oftalmologia, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2718-5976","authenticated-orcid":false,"given":"Mun","family":"Faria","sequence":"additional","affiliation":[{"name":"Ophthalmology, Hospital de Santa Maria - Unidade Local de Sa\u00fade de Santa Maria, Lisbon, Portugal"},{"name":"Cl\u00ednica Universit\u00e1ria de Oftalmologia, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Pinto Ferreira","sequence":"additional","affiliation":[{"name":"Ophthalmology, Hospital de Santa Maria - Unidade Local de Sa\u00fade de Santa Maria, Lisbon, Portugal"},{"name":"Cl\u00ednica Universit\u00e1ria de Oftalmologia, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"2026082803551819000_19.8.e274277.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)00512-6"},{"key":"2026082803551819000_19.8.e274277.2","doi-asserted-by":"crossref","unstructured":"Gaudric A , Paques M , Massin P , et al . Use of autologous platelet concentrate in macular hole surgery: report of 77 cases. In: Macular and retinal diseases. Basel: Karger, 1997: 30\u20135. Available: https:\/\/doi.org\/10.1159\/000060724","DOI":"10.1159\/000060724"},{"key":"2026082803551819000_19.8.e274277.3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/clinpract12010007","article-title":"Plasma Rich in Growth Factors in Macular Hole Surgery","volume":"12","author":"S\u00e1nchez-\u00c1vila","year":"2022","journal-title":"Clin Pract"},{"key":"2026082803551819000_19.8.e274277.4","doi-asserted-by":"crossref","first-page":"e605","DOI":"10.1111\/aos.12710","article-title":"Autologous serum and plasma rich in growth factors in ophthalmology: preclinical and clinical studies","volume":"93","author":"Anitua","year":"2015","journal-title":"Acta Ophthalmol"},{"key":"2026082803551819000_19.8.e274277.5","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1007\/s00417-023-06365-x","article-title":"Platelet concentrates in macular hole surgery. A journey through the labyrinth of terminology, preparation, and application: a comprehensive review","volume":"262","author":"Gelormini","year":"2024","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"2026082803551819000_19.8.e274277.6","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.oftal.2016.03.001","article-title":"Plasma rico en plaquetas en superficie ocular","volume":"91","author":"Riestra","year":"2016","journal-title":"Archivos de La Sociedad Espa\u00f1ola de Oftalmolog\u00eda"},{"key":"2026082803551819000_19.8.e274277.7","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1089\/jop.2016.0166","article-title":"The Effect of Immunologically Safe Plasma Rich in Growth Factor Eye Drops in Patients with Sj\u00f6gren Syndrome","volume":"33","author":"Sanchez-Avila","year":"2017","journal-title":"J Ocul Pharmacol Ther"},{"key":"2026082803551819000_19.8.e274277.8","article-title":"Retinal Inflammation and Reactive M\u00fcller Cells: Neurotrophins\u2019 Release and Neuroprotective Strategies","volume":"13","author":"Balzamino","year":"2024","journal-title":"Biology (Basel)"},{"key":"2026082803551819000_19.8.e274277.9","doi-asserted-by":"publisher","DOI":"10.1097\/iio.0000000000000258"},{"key":"2026082803551819000_19.8.e274277.10","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s10792-020-01325-4","article-title":"Inflammatory mediators of proliferative vitreoretinopathy: hypothesis and review","volume":"40","author":"Dai","year":"2020","journal-title":"Int Ophthalmol"},{"key":"2026082803551819000_19.8.e274277.11","first-page":"1794","article-title":"Early and Pronounced PVR Reaction After Revitrectomy With Allogeneic Platelet Concentrate in Persistent Macular Hole","volume":"33","author":"Fisel","year":"2026","journal-title":"Case Rep Ophthalmol Med"},{"key":"2026082803551819000_19.8.e274277.12","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1080\/09273948.2025.2486363","article-title":"First Case Report of Successful Use of ILM Peeling, Inverted Flap and PRGF-Endoret\u00ae in Bilateral Macular Hole in Beh\u00e7et\u2019s Disease","volume":"33","author":"Bertolani","year":"2025","journal-title":"Ocul Immunol Inflamm"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2026-274277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:55:22Z","timestamp":1787914522000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2026-274277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":12,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8,28]]},"published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1136\/bcr-2026-274277"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2026-274277","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]}}}