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This case highlights a rare occurrence of sporadic gNETs following prolonged PPI use and underscores the importance of judicious use of PPIs in patients with chronic GERD symptoms.<\/jats:p>","DOI":"10.1136\/bcr-2026-276189","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:43:26Z","timestamp":1790862206000},"page":"e276189","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Gastric neuroendocrine tumours after prolonged proton pump inhibitor use"],"prefix":"10.1136","volume":"19","author":[{"given":"Janet","family":"Song","sequence":"first","affiliation":[{"name":"Internal Medicine, Kaiser Permanente Santa Clara Medical Center, Santa Clara, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Bien","sequence":"additional","affiliation":[{"name":"Hematology\/Oncology, Kaiser Permanente Santa Clara Medical Center, Santa Clara, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Hristova","sequence":"additional","affiliation":[{"name":"Pathology, Kaiser Permanente Santa Clara Medical Center, Santa Clara, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrisy","family":"Mafnas","sequence":"additional","affiliation":[{"name":"Pathology, Kaiser Permanente Santa Clara Medical Center, Santa Clara, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California, Pleasanton, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"2026100106251801000_19.10.e276189.1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-024-00508-y","article-title":"Gastric neuroendocrine neoplasms","volume":"10","author":"Lamberti","year":"2024","journal-title":"Nat Rev Dis Primers"},{"key":"2026100106251801000_19.10.e276189.2","unstructured":"National Comprehensive Cancer Network . 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The chromogranin\u2013secretogranin family. 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