{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T15:40:02Z","timestamp":1745595602903,"version":"3.40.4"},"reference-count":21,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Essential thrombocythaemia (ET) is a rare chronic myeloproliferative disease characterised by persistent thrombocytosis. Cerebral, myocardial and peripheral thrombosis are frequently seen complications, but bleeding and venous thrombosis are more rare. Here, a case of essential thrombocythaemia complicated by cerebral and myocardial thrombosis is presented. The patient\u2019s platelet count was 680\u00d710<jats:sup>9<\/jats:sup>\/litre on admission. Electrocardiogram showed a slight ST elevation in leads V1 to V4. A coronary angiography was performed and it revealed a severe stenosis of the left anterior descending artery. The patient had a successful off-pump coronary artery bypass grafting surgery. After the operation the platelet count was 390\u00d710<jats:sup>9<\/jats:sup>\/litre. The patient received hydroxyurea and aspirin treatment preoperatively and continued postoperatively. ET is a rare myeloproliferative disease; its complications are also rare, but the occurrence of two life-threatening complications in the same patient is rarer still. Further investigations are needed to determine the risk stratification for patients with ET undergoing cardiac surgery.<\/jats:p>","DOI":"10.1136\/bcr.01.2009.1503","type":"journal-article","created":{"date-parts":[[2009,8,26]],"date-time":"2009-08-26T05:10:30Z","timestamp":1251263430000},"page":"bcr0120091503","source":"Crossref","is-referenced-by-count":1,"title":["Off-pump coronary artery surgery in a patient with essential thrombocythaemia: two life-threatening complications in the same patient"],"prefix":"10.1136","volume":"2009","author":[{"given":"Kaan","family":"Kaya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raif","family":"Cavolli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alpaslan","family":"Telli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Refik","family":"Tasoz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2009,8,25]]},"reference":[{"issue":"Suppl 3","key":"2025042508115986000_2009.aug25_1.bcr0120091503.1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/j.seminhematol.2004.02.011","article-title":"The chronic myeloproliferative disorders: clonality and clinical heterogeneity","volume":"41","author":"Spivak","year":"2004","journal-title":"Semin Hematol"},{"key":"2025042508115986000_2009.aug25_1.bcr0120091503.2","first-page":"69","article-title":"Essential thrombocythemia","volume":"10","author":"Schafer","year":"1991","journal-title":"Prog Hemost Thromb"},{"key":"2025042508115986000_2009.aug25_1.bcr0120091503.3","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-8807(03)00055-3"},{"key":"2025042508115986000_2009.aug25_1.bcr0120091503.4","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/BF03217818","article-title":"A case of coronary artery bypass surgery using the left internal thoracic artery and right gastroepiploic artery for a patient with essential thrombocythemia","volume":"46","author":"Ohto","year":"1998","journal-title":"Jpn J Thorac Cardiovasc Surg"},{"key":"2025042508115986000_2009.aug25_1.bcr0120091503.5","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8090-3-5"},{"key":"2025042508115986000_2009.aug25_1.bcr0120091503.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.01.055"},{"key":"2025042508115986000_2009.aug25_1.bcr0120091503.7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1182\/blood.V82.1.107.bloodjournal821107","article-title":"The platelet function defect of cardiopulmonary bypass","volume":"82","author":"Kestin","year":"1993","journal-title":"Blood"},{"key":"2025042508115986000_2009.aug25_1.bcr0120091503.8","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/BF01891529","article-title":"Hemorrhagic thrombocythemia with a vascular, sclerotic spleen","volume":"293","author":"Epstein","year":"1934","journal-title":"Virchows Archiv A Pathol Anat Histopathol"},{"key":"2025042508115986000_2009.aug25_1.bcr0120091503.9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-083501"},{"key":"2025042508115986000_2009.aug25_1.bcr0120091503.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051113"},{"key":"2025042508115986000_2009.aug25_1.bcr0120091503.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.03.023"},{"key":"2025042508115986000_2009.aug25_1.bcr0120091503.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67785-9"},{"key":"2025042508115986000_2009.aug25_1.bcr0120091503.13","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0175"},{"key":"2025042508115986000_2009.aug25_1.bcr0120091503.14","doi-asserted-by":"crossref","unstructured":"Levine RL Heaney M . 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