{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:55:12Z","timestamp":1788897312267,"version":"build-2803163510"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Recombinant human parathyroid hormone (1\u201334) (rhPTH 1\u201334), teriparatide (Forsteo in Europe), is a new compound that has been introduced and shown to be successful in the treatment of osteoporosis. The mechanisms of action include a pulsative influence on the RANKL\/OPG system resulting in osteoblast activation and increased bone formation by teriparatide. In malignant myeloma there is an imbalance between osteoclast and osteoblast activity with involvement of the RANKL\/OPG system among others. We report a case with monoclonal gammopathy of uncertain significance (MGUS) who developed malignant myeloma after teriparatide treatment and we suggest that in addition to malignant myeloma and smouldering myeloma, MGUS should also be considered contraindicated for teriparatide treatment.<\/jats:p>","DOI":"10.1136\/bcr.01.2010.2681","type":"journal-article","created":{"date-parts":[[2010,8,16]],"date-time":"2010-08-16T15:28:29Z","timestamp":1281972509000},"page":"bcr0120102681","source":"Crossref","is-referenced-by-count":20,"title":["Teriparatide treatment complicated by malignant myeloma"],"prefix":"10.1136","volume":"2010","author":[{"given":"Anna-Mari","family":"Koski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Siki\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terje","family":"Forslund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2010,8,16]]},"reference":[{"key":"2025042508403049000_2010.aug11_1.bcr0120102681.1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2004-0006"},{"key":"2025042508403049000_2010.aug11_1.bcr0120102681.2","doi-asserted-by":"publisher","DOI":"10.1210\/en.142.2.916"},{"key":"2025042508403049000_2010.aug11_1.bcr0120102681.3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.280.6228.1340"},{"key":"2025042508403049000_2010.aug11_1.bcr0120102681.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105103441904"},{"key":"2025042508403049000_2010.aug11_1.bcr0120102681.5","doi-asserted-by":"publisher","DOI":"10.1080\/01926230252929882"},{"key":"2025042508403049000_2010.aug11_1.bcr0120102681.6","first-page":"119","article-title":"Malignant myeloma in a patient after treatment for osteoporosis with teriparatide: a rare coincidence","volume":"1","author":"Forslund","year":"2008","journal-title":"Clin Med Case Rep"},{"key":"2025042508403049000_2010.aug11_1.bcr0120102681.7","first-page":"1655","article-title":"Immunophenotypic characterization of plasma cells from monoclonal gammopathy of undetermined significance patients. Implications for the differential diagnosis between MGUS and multiple myeloma","volume":"152","author":"Ocqueteau","year":"1998","journal-title":"Am J Pathol"},{"key":"2025042508403049000_2010.aug11_1.bcr0120102681.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp052790"},{"key":"2025042508403049000_2010.aug11_1.bcr0120102681.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054494"},{"key":"2025042508403049000_2010.aug11_1.bcr0120102681.10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-032066"},{"key":"2025042508403049000_2010.aug11_1.bcr0120102681.11","first-page":"502","article-title":"Secretion of parathyroid hormone-related peptide in patients with multiple myeloma","volume":"63","author":"Beaudreuil","year":"1996","journal-title":"Rev Rhum Engl Ed"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.01.2010.2681","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T15:40:38Z","timestamp":1745595638000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.01.2010.2681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":11,"alternative-id":["10.1136\/bcr.01.2010.2681"],"URL":"https:\/\/doi.org\/10.1136\/bcr.01.2010.2681","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}