{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T07:05:20Z","timestamp":1769238320497,"version":"3.49.0"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Malignant mesothelioma is an uncommon neoplasia which primarily involves the pleura or peritoneum. Central nervous system involvement is rare. A rare presentation of metastatic pleural mesothelioma, which had infiltrated the meninges and brainstem, is described. The patient presented with diplopia following a 2-week history of malaise, myalgia, mild headache and diarrhoea. Clinical examination found global areflexia, cerebellar ataxia and bilateral sixth nerve palsies. Differential diagnoses included the Miller\u2013Fisher variant of Guillain\u2013Barre syndrome, malignant meningitis and infectious meningitis. The patient was treated with immunoglobulins, plasmaphoresis and corticosteroids; however, he deteriorated and died 31 days after admission. Retrospective examination of the MRI of the brain found diffuse low attenuation changes within the pons and cerebral peduncles. Postmortem examination favoured a diagnosis of an early sarcomatoid malignant mesothelioma of pleural origin with leptomeningeal metastatic deposits.<\/jats:p>","DOI":"10.1136\/bcr.02.2010.2755","type":"journal-article","created":{"date-parts":[[2010,11,5]],"date-time":"2010-11-05T13:34:55Z","timestamp":1288964095000},"page":"bcr0220102755","source":"Crossref","is-referenced-by-count":1,"title":["Meningeal and brainstem infiltration by a malignant mesothelioma"],"prefix":"10.1136","volume":"2010","author":[{"given":"Kim","family":"Wild","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasanna","family":"Sankaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Sington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2010,11,5]]},"reference":[{"key":"2025082805071819000_2010.nov04_1.bcr0220102755.1","first-page":"260","article-title":"Diffuse pleural mesothelioma and asbestos exposure in the North Western Cape Province","volume":"17","author":"Wagner","year":"1960","journal-title":"Br J Ind Med"},{"key":"2025082805071819000_2010.nov04_1.bcr0220102755.2","first-page":"591","article-title":"Intracranial metastases from malignant pleural mesothelioma. Report of three autopsy cases and review of the literature","volume":"115","author":"Falconieri","year":"1991","journal-title":"Arch Pathol Lab Med"},{"key":"2025082805071819000_2010.nov04_1.bcr0220102755.3","doi-asserted-by":"publisher","DOI":"10.1136\/thx.42.11.897"},{"key":"2025082805071819000_2010.nov04_1.bcr0220102755.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2004.05.005"},{"key":"2025082805071819000_2010.nov04_1.bcr0220102755.5","doi-asserted-by":"publisher","DOI":"10.1007\/BF01054270"},{"key":"2025082805071819000_2010.nov04_1.bcr0220102755.6","doi-asserted-by":"publisher","DOI":"10.1385\/MO:19:3:167"},{"key":"2025082805071819000_2010.nov04_1.bcr0220102755.7","first-page":"1223","article-title":"Leptomeningeal metastasis from malignant pleural mesothelioma","volume":"25","author":"Petrovic","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"2025082805071819000_2010.nov04_1.bcr0220102755.8","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820215)49:4<759::AID-CNCR2820490427>3.0.CO;2-7"},{"key":"2025082805071819000_2010.nov04_1.bcr0220102755.9","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1996.00550070064013"},{"key":"2025082805071819000_2010.nov04_1.bcr0220102755.10","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005956925637"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.02.2010.2755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:07:23Z","timestamp":1756382843000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.02.2010.2755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":10,"alternative-id":["10.1136\/bcr.02.2010.2755"],"URL":"https:\/\/doi.org\/10.1136\/bcr.02.2010.2755","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}