{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:21:00Z","timestamp":1760898060145,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Dermatomyositis (DM) is a rare inflammatory autoimmune disease for which an iatrogenic origin has been described in a few cases. The authors report a case of DM occurring after simvastatin intake.<\/jats:p>\n               <jats:p>A 50-year-old male sought medical attention for a photodistributed rash and considerable muscular weakness present for 3 months. One year earlier, simvastatin had been introduced. Serum creatine kinase levels were elevated. Histological examination of a muscle biopsy was consistent with a diagnosis of DM. Investigation for neoplasia and associated autoimmune disease proved negative. All clinical and laboratory abnormalities diminished corticosteroid therapy (1 mg\/kg\/day).<\/jats:p>\n               <jats:p>Case reports have suggested that lipid-lowering drugs, especially statins, could induce or reveal chronic muscle diseases. In statins myopathy, reduction of coenzyme Q has been discussed as a key mechanism. Our case of DM in a patient receiving simvastatin adds to the previous reported cases in the literature and highlights the potential role of statins as triggers of immune systemic diseases.<\/jats:p>","DOI":"10.1136\/bcr.02.2011.3832","type":"journal-article","created":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T06:46:04Z","timestamp":1301467564000},"page":"bcr0220113832","source":"Crossref","is-referenced-by-count":10,"title":["Simvastatin-induced dermatomyositis in a 50-year-old man"],"prefix":"10.1136","volume":"2011","author":[{"given":"In\u00e9s Rania","family":"Zaraa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imen","family":"Labb\u00e8ne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalila","family":"Mrabet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hela","family":"Zribi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00e8s","family":"Chelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Zitouna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mourad","family":"Mokni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slaheddine","family":"Sellami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amel Ben","family":"Osman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2011,3,30]]},"reference":[{"key":"2025082805141278000_2011.mar29_1.bcr0220113832.1","doi-asserted-by":"crossref","first-page":"486","DOI":"10.5694\/j.1326-5377.2001.tb143683.x","article-title":"Statin-associated myopathy.","volume":"175","author":"Hamilton-Craig","year":"2001","journal-title":"Med J Aust"},{"key":"2025082805141278000_2011.mar29_1.bcr0220113832.2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.13.1681"},{"key":"2025082805141278000_2011.mar29_1.bcr0220113832.3","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.075523"},{"key":"2025082805141278000_2011.mar29_1.bcr0220113832.4","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32830e2774"},{"key":"2025082805141278000_2011.mar29_1.bcr0220113832.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.05.034"},{"key":"2025082805141278000_2011.mar29_1.bcr0220113832.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01838.x"},{"key":"2025082805141278000_2011.mar29_1.bcr0220113832.7","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/33.2.199"},{"key":"2025082805141278000_2011.mar29_1.bcr0220113832.8","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1445-5994.1995.tb02870.x","article-title":"Dermatomyositis with lung involvement in a patient treated with simvastatin.","volume":"25","author":"Hill","year":"1995","journal-title":"Aust N Z J Med"},{"key":"2025082805141278000_2011.mar29_1.bcr0220113832.9","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20127"},{"key":"2025082805141278000_2011.mar29_1.bcr0220113832.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09205.x"},{"key":"2025082805141278000_2011.mar29_1.bcr0220113832.11","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-008-1637-5"},{"key":"2025082805141278000_2011.mar29_1.bcr0220113832.12","doi-asserted-by":"publisher","DOI":"10.2165\/0129784-200808060-00004"},{"key":"2025082805141278000_2011.mar29_1.bcr0220113832.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02030-2"},{"key":"2025082805141278000_2011.mar29_1.bcr0220113832.14","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328314b7b4"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.02.2011.3832","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:14:18Z","timestamp":1756383258000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.02.2011.3832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":14,"alternative-id":["10.1136\/bcr.02.2011.3832"],"URL":"https:\/\/doi.org\/10.1136\/bcr.02.2011.3832","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2011]]}}}