{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T12:41:50Z","timestamp":1770381710335,"version":"3.49.0"},"reference-count":18,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Vitamin B<jats:sub>12<\/jats:sub>or cobalamin deficiency, a rare clinical entity in pediatric age, is found most exclusively in breastfed infants, whose mothers are strictly vegetarian non-supplemented or with pernicious anaemia. In this article, the authors describe a 10-month-old infant admitted for vomiting, refusal to eat and prostration. The infant was exclusively breastfed and difficulties in introduction of new foods were reported. Failure to thrive since 5 months of age was also noticed. Laboratory evaluation revealed severe normocytic normochromic anaemia and cobalamin deficit. A diagnosis of \u03b1-thalassemia trait was also made. Maternal investigation showed autoimmune pernicious anaemia. This case shows the severity of vitamin B<jats:sub>12<\/jats:sub>deficiency and the importance of adopting adequate and precocious measures in order to prevent potentially irreversible neurologic damage.<\/jats:p>","DOI":"10.1136\/bcr.02.2011.3835","type":"journal-article","created":{"date-parts":[[2011,5,17]],"date-time":"2011-05-17T10:43:29Z","timestamp":1305629009000},"page":"bcr0220113835","source":"Crossref","is-referenced-by-count":7,"title":["Severe megaloblastic anaemia in an infant"],"prefix":"10.1136","volume":"2011","author":[{"given":"Vera","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Dias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jo\u00e3o","family":"Brito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Galv\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gon\u00e7alo Cordeiro","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2011,5,17]]},"reference":[{"key":"2025042707361510000_2011.may15_1.bcr0220113835.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2008.00031.x"},{"key":"2025042707361510000_2011.may15_1.bcr0220113835.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.01.023"},{"key":"2025042707361510000_2011.may15_1.bcr0220113835.3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.8.979"},{"key":"2025042707361510000_2011.may15_1.bcr0220113835.4","doi-asserted-by":"publisher","DOI":"10.1080\/08880010802016789"},{"key":"2025042707361510000_2011.may15_1.bcr0220113835.5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.24.012003.132440"},{"key":"2025042707361510000_2011.may15_1.bcr0220113835.6","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200404000-00013"},{"key":"2025042707361510000_2011.may15_1.bcr0220113835.7","doi-asserted-by":"publisher","DOI":"10.1136\/dtb.2009.01.0002"},{"key":"2025042707361510000_2011.may15_1.bcr0220113835.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.01059.x"},{"key":"2025042707361510000_2011.may15_1.bcr0220113835.9","doi-asserted-by":"publisher","DOI":"10.3109\/08880018909034282"},{"key":"2025042707361510000_2011.may15_1.bcr0220113835.10","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181d74719"},{"key":"2025042707361510000_2011.may15_1.bcr0220113835.11","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1182\/blood.V9.6.648.648","article-title":"Mediterranean anemia in a Negro complicated by pernicious anemia of pregnancy: report of a case.","volume":"9","author":"Goldberg","year":"1954","journal-title":"Blood"},{"key":"2025042707361510000_2011.may15_1.bcr0220113835.12","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181b7edb5"},{"key":"2025042707361510000_2011.may15_1.bcr0220113835.13","unstructured":"Lichtman MA Beutler E Kipps TJ . 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