{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:01:04Z","timestamp":1777561264876,"version":"3.51.4"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Bartter syndrome is a group of rare autosomal-recessive disorders caused by a defect in distal tubule transport of sodium and chloride. Blood gases and plasma electrolytes raise suspicion of this diagnosis and the definitive diagnosis is made by genetic study. Early treatment improves prognosis. The authors present the case of an 11-month-old child with early failure to thrive and severe regurgitation. Blood gases revealed hypochloraemic metabolic alkalosis, hyponatraemia and hypokalaemia. Blood pressure was normal and polyuria was documented. She began therapy with potassium chloride supplementation and indomethacin. There was clinical improvement and plasma potassium and bicarbonate normalised. The molecular study confirmed it was the classic form of Bartter syndrome. Despite being rare in clinical practice, which may lead to unnecessary medical investigation and diagnosis delay, in a child with failure to thrive, hypochloraemic metabolic alkalosis and hypokalaemia, this diagnosis must be considered.<\/jats:p>","DOI":"10.1136\/bcr.02.2012.5888","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T14:43:35Z","timestamp":1340894615000},"page":"bcr0220125888","source":"Crossref","is-referenced-by-count":8,"title":["Classic Bartter syndrome: a rare cause of failure to thrive in a child: Table 1"],"prefix":"10.1136","volume":"2012","author":[{"given":"Helena","family":"Vieira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonor","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Esteves","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,6,28]]},"reference":[{"key":"2025042702225474000_2012.jun28_1.bcr0220125888.1","unstructured":"Rodr\u00edguez-Soriano J . S\u00edndrome de Bartter y syndromes afines. In: Paniagua G Exeni R Cruz J . Nefrologia Pediatrica. Second Edition. Espanha: Elsevier Science 2003:289\u2013300."},{"key":"2025042702225474000_2012.jun28_1.bcr0220125888.2","doi-asserted-by":"crossref","unstructured":"Waldegger S . Bartter, Gitelman, and Related Syndromes. In: Geary DF Schaefer F . Comprehensive Pediatric Nephrology. First Edition. Philadelphia, PA: Mosby 2008:451\u20139.","DOI":"10.1016\/B978-0-323-04883-5.50035-0"},{"key":"2025042702225474000_2012.jun28_1.bcr0220125888.3","unstructured":"Bartter\u2019s and Gitelman\u2019s Syndromes, 2011. http:\/\/www.uptodate.com (accessed August 2011)."},{"key":"2025042702225474000_2012.jun28_1.bcr0220125888.4","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200112000-00004"},{"key":"2025042702225474000_2012.jun28_1.bcr0220125888.5","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200309000-00008"},{"key":"2025042702225474000_2012.jun28_1.bcr0220125888.6","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn689"},{"key":"2025042702225474000_2012.jun28_1.bcr0220125888.7","unstructured":"Asociaci\u00f3n Espanola de Pediatr\u00eda. Protocolos de Nefrolog\u00eda Pedi\u00e1trica AEP, 2008. http:\/\/www.aeped.es\/protocolos\/ (accessed August 2011)."},{"key":"2025042702225474000_2012.jun28_1.bcr0220125888.8","unstructured":"Unexplained metabolic alkalosis and hypokalemia: vomiting, diuretics, Gitelman\u2019s or Bartter\u2019s syndrome, 2006. http:\/\/www.uptodate.com (accessed August 2011)."},{"key":"2025042702225474000_2012.jun28_1.bcr0220125888.9","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0912"},{"key":"2025042702225474000_2012.jun28_1.bcr0220125888.10","doi-asserted-by":"crossref","first-page":"p73","DOI":"10.1159\/000094001","article-title":"Bartter syndromes and other salt-losing tubulopathies.","volume":"104","author":"Kleta","year":"2006","journal-title":"Nephron Physiol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.02.2012.5888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T09:23:09Z","timestamp":1745745789000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.02.2012.5888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,28]]},"references-count":10,"alternative-id":["10.1136\/bcr.02.2012.5888"],"URL":"https:\/\/doi.org\/10.1136\/bcr.02.2012.5888","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,28]]}}}