{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:10:09Z","timestamp":1756368609078,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>The usual reason for measuring serum amylase level is to confirm or exclude the diagnosis of pancreatitis. However, increases in serum amylase levels can occur in conditions other than pancreatitis and many of those conditions present with acute abdominal pain. In the case presented here, an unconscious patient developed a very high serum total amylase level, which was most likely due to hypoxemia and lactic acidosis secondary to an overdose of Tramadol (Nobligan) tablets. The patient was treated in the intensive care unit and had an uneventful recovery. Many diseases can cause acute elevation of serum amylase level. In lactic acidosis, the hyperamylasemia typically results from the presence of excessive salivary-type isoamylase. Therefore, isoamylase enzyme analysis is of great clinical value in the differential diagnosis of hyperamylasemia, especially in cases with concurrent lactic acidosis.<\/jats:p>","DOI":"10.1136\/bcr.03.2010.2821","type":"journal-article","created":{"date-parts":[[2010,8,10]],"date-time":"2010-08-10T11:06:17Z","timestamp":1281438377000},"page":"bcr0320102821","source":"Crossref","is-referenced-by-count":7,"title":["Tramadol poisoning with hyperamylasemia: Figure 1"],"prefix":"10.1136","volume":"2010","author":[{"given":"Alaa","family":"El-Hussuna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regnar B\u00f8ge","family":"Arnesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2010,8,10]]},"reference":[{"key":"2025082800370038000_2010.aug06_1.bcr0320102821.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(88)80112-0"},{"key":"2025082800370038000_2010.aug06_1.bcr0320102821.2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.331.7521.890"},{"key":"2025082800370038000_2010.aug06_1.bcr0320102821.3","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0889-8553(21)00514-8","article-title":"Where does serum amylase come from and where does it go?","volume":"19","author":"Pieper-Bigelow","year":"1990","journal-title":"Gastroenterol Clin North Am"},{"key":"2025082800370038000_2010.aug06_1.bcr0320102821.4","first-page":"1472","volume":"Vol 2","author":"Schwartz","year":"1999","journal-title":"Principles of surgery"},{"key":"2025082800370038000_2010.aug06_1.bcr0320102821.5","first-page":"480","article-title":"Elevated serum amylase activity in the absence of clinical pancreatic or salivary gland disease: possible role of acute hypoxemia","volume":"70","author":"Jam","year":"1978","journal-title":"Am J Gastroenterol"},{"key":"2025082800370038000_2010.aug06_1.bcr0320102821.6","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-198204000-00008"},{"key":"2025082800370038000_2010.aug06_1.bcr0320102821.7","first-page":"358","article-title":"Clinical value of routine isoamylase analysis of hyperamylasemia","volume":"81","author":"Kameya","year":"1986","journal-title":"Am J Gastroenterol"},{"key":"2025082800370038000_2010.aug06_1.bcr0320102821.8","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1097\/00005373-198011000-00008","article-title":"Hyperamylasemia in critically injured patients","volume":"20","author":"Takahashi","year":"1980","journal-title":"J Trauma"},{"key":"2025082800370038000_2010.aug06_1.bcr0320102821.9","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(77)90240-6"},{"key":"2025082800370038000_2010.aug06_1.bcr0320102821.10","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198608000-00011"},{"key":"2025082800370038000_2010.aug06_1.bcr0320102821.11","doi-asserted-by":"publisher","DOI":"10.1157\/13075703"},{"key":"2025082800370038000_2010.aug06_1.bcr0320102821.12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.03213.x"},{"key":"2025082800370038000_2010.aug06_1.bcr0320102821.13","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199301000-00022"},{"key":"2025082800370038000_2010.aug06_1.bcr0320102821.14","unstructured":"The web site of the Danish Medicines Agency. http:\/\/www.produktresume.dk\/docushare\/dsweb\/GetRendition\/Document-27558\/html (Accessed 11 January 2010)."},{"key":"2025082800370038000_2010.aug06_1.bcr0320102821.15","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4942.770"},{"key":"2025082800370038000_2010.aug06_1.bcr0320102821.16","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-102-5-576"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.03.2010.2821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:37:08Z","timestamp":1756366628000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.03.2010.2821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":16,"alternative-id":["10.1136\/bcr.03.2010.2821"],"URL":"https:\/\/doi.org\/10.1136\/bcr.03.2010.2821","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2010]]}}}