{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T04:07:57Z","timestamp":1745640477567,"version":"3.40.4"},"reference-count":17,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>A 95-year-old woman had been treated over the past 8 years for progressive dysphagia. When her condition worsened, blood tests revealed the presence of leucocytosis and eosinophilia in the absence of anaemia or thrombocytopenia. Within 11 days of diagnosis, the patient died of respiratory failure. Necropsy showed normal thyroid tissue and an absence of infectious disease. However, an upper mediastinal tumour was found and was histopathologically diagnosed as a neoplastic transformation of the ectopic thyroid. Only 1% of endothoracic goitres present as ectopic or autonomous goitre with no parenchymal or vascular connection to the thyroid gland. This case represents a very rare situation in which a leukemoid reaction and peripheral hypereosinophilia were observed as a manifestation of an anaplastic thyroid carcinoma in an ectopic mass.<\/jats:p>","DOI":"10.1136\/bcr.03.2010.2823","type":"journal-article","created":{"date-parts":[[2010,8,31]],"date-time":"2010-08-31T13:37:45Z","timestamp":1283261865000},"page":"bcr0320102823","source":"Crossref","is-referenced-by-count":4,"title":["A 95-year-old woman with leucocytosis and eosinophilia: anaplastic carcinoma in an ectopic thyroid"],"prefix":"10.1136","volume":"2010","author":[{"given":"Einstein Francisco","family":"Camargos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela Basso","family":"Pandolfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Alice V","family":"Toledo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Lima","family":"Quintas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebasti\u00e3o","family":"Moreira-Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Em\u00edlia Borges","family":"de Azevedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Cavalca","family":"Tavares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2010,8,31]]},"reference":[{"key":"2025042508422487000_2010.aug28_1.bcr0320102823.1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mrfmmm.2006.01.021","article-title":"Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions","volume":"599","author":"Pavelic","year":"2006","journal-title":"Mutat Res"},{"key":"2025042508422487000_2010.aug28_1.bcr0320102823.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2003.11.002"},{"key":"2025042508422487000_2010.aug28_1.bcr0320102823.3","first-page":"193","article-title":"Scintigraphic identification of complete thoracic goiter with normal appearing cervical thyroid: a case report","volume":"25","author":"Kaplan","year":"1974","journal-title":"J Can Assoc Radiol"},{"key":"2025042508422487000_2010.aug28_1.bcr0320102823.4","first-page":"889","article-title":"Retrosternal goiter: a six-year institutional review","volume":"64","author":"Moron","year":"1998","journal-title":"Am Surg"},{"key":"2025042508422487000_2010.aug28_1.bcr0320102823.5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0749-0690(18)30297-0","article-title":"Neoplasm of the thyroid gland","volume":"11","author":"Gupta","year":"1995","journal-title":"Clin Geriatr Med"},{"key":"2025042508422487000_2010.aug28_1.bcr0320102823.6","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197806)41:6<2267::AID-CNCR2820410627>3.0.CO;2-7"},{"key":"2025042508422487000_2010.aug28_1.bcr0320102823.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2004.03062.x"},{"key":"2025042508422487000_2010.aug28_1.bcr0320102823.8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2000.00598.x"},{"key":"2025042508422487000_2010.aug28_1.bcr0320102823.9","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900715)66:2<321::AID-CNCR2820660221>3.0.CO;2-A"},{"key":"2025042508422487000_2010.aug28_1.bcr0320102823.10","first-page":"478","article-title":"[An eosinophilic leukemoid reaction associated with anaplastic carcinoma of the thyroid]","volume":"95","author":"Guti\u00c3\u00a9rrez-Marcos","year":"1990","journal-title":"Med Clin (Barc)"},{"key":"2025042508422487000_2010.aug28_1.bcr0320102823.11","doi-asserted-by":"crossref","first-page":"303","DOI":"10.14310\/horm.2002.11196","article-title":"Papillary thyroid carcinoma producing granulocyte-macrophage colony-stimulating factor is associated with neutrophilia and eosinophilia","volume":"5","author":"Vassilatou","year":"2006","journal-title":"Hormones (Athens)"},{"key":"2025042508422487000_2010.aug28_1.bcr0320102823.12","first-page":"55","article-title":"[A case report of thyroid papillary cancer that manifested leukocytosis and hypercalcemia after radiotherapy in bone metastasis]","volume":"35","author":"Kobayashi","year":"1989","journal-title":"Gan No Rinsho"},{"key":"2025042508422487000_2010.aug28_1.bcr0320102823.13","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1002\/1097-0142(19891201)64:11<2250::AID-CNCR2820641111>3.0.CO;2-X","article-title":"Paraneoplastic eosinophilia. 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