{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:39:29Z","timestamp":1787683169011,"version":"build-2784847793"},"reference-count":9,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Most oesophageal carcinomas (&gt;70%) are squamous cell carcinomas (SCC) arising from the surface epithelial lining. In the gastro-oesophageal junction (GEJ) adenocarcinomas occur in the setting of Barrett oesophagus (BE). These carcinomas typically present with surface ulceration. The authors report a rare case of a SCC of the GEJ with completely intramural growth underneath intact non-dysplastic oesophageal squamous epithelium and BE without dysplasia. The sharply demarcated tumour was located in the muscularis propia with infiltration of perioesophageal tissue nearly reaching the diaphragm. Intramural squamous carcinomas are very rare with only three reported cases. In this study, the authors discuss this finding and review the relevant literature. Intramural carcinomas are a diagnostic challenge for clinicians and pathologist, since preoperative biopsies mostly fail to establish the diagnosis and surgical explorations must be considered.<\/jats:p>","DOI":"10.1136\/bcr.03.2012.6080","type":"journal-article","created":{"date-parts":[[2012,7,11]],"date-time":"2012-07-11T11:59:33Z","timestamp":1342007973000},"page":"bcr0320126080","source":"Crossref","is-referenced-by-count":11,"title":["Intramural carcinoma of the oesophagogastric junction"],"prefix":"10.1136","volume":"2012","author":[{"given":"Klaus J\u00fcrgen","family":"Schmitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus Peter","family":"Riesener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,7,11]]},"reference":[{"key":"2025082803390561000_2012.jul11_1.bcr0320126080.1","doi-asserted-by":"crossref","unstructured":"Sobin LH Gospodarowicz MKWC . TNM Classification of Malignant Tumours. Seventh Edition. New York, USA: Wiley-Liss 2009.","DOI":"10.1002\/9780471420194.tnmc26"},{"key":"2025082803390561000_2012.jul11_1.bcr0320126080.2","unstructured":"Parkin DM Whelan SL Ferlay J . Cancer Incidence in Five Continents. Lyon: IARC 2002."},{"key":"2025082803390561000_2012.jul11_1.bcr0320126080.3","unstructured":"Bosman FT Carneiro F Hruban RH Theise ND , eds. WHO classification of Tumours of the Digestive System. Lyon: IARC 2010."},{"key":"2025082803390561000_2012.jul11_1.bcr0320126080.4","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880175"},{"key":"2025082803390561000_2012.jul11_1.bcr0320126080.5","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197603)37:3<1556::AID-CNCR2820370345>3.0.CO;2-E"},{"key":"2025082803390561000_2012.jul11_1.bcr0320126080.6","first-page":"1581","article-title":"Submucosal tumor (SMT)-like esophageal squamous cell carcinoma with gastric metastasis.","volume":"47","author":"Kishino","year":"2000","journal-title":"Hepatogastroenterology"},{"key":"2025082803390561000_2012.jul11_1.bcr0320126080.7","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-006-0185-6"},{"key":"2025082803390561000_2012.jul11_1.bcr0320126080.8","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.13.5.8210590"},{"key":"2025082803390561000_2012.jul11_1.bcr0320126080.9","doi-asserted-by":"crossref","unstructured":"Enterline H Thomson J . Pathology of the Esophagus. New York: Springer-Verlag 1984.","DOI":"10.1007\/978-1-4612-5216-0"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.03.2012.6080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:39:12Z","timestamp":1756377552000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.03.2012.6080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,11]]},"references-count":9,"alternative-id":["10.1136\/bcr.03.2012.6080"],"URL":"https:\/\/doi.org\/10.1136\/bcr.03.2012.6080","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,11]]}}}