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An 8 week trial of total parenteral nutrition, in addition to corticosteroids, salazopyrine, metronidazole, and azathioprine failed to arrest deterioration of the perianal fistulas. Treatment with the anti-TNF\u03b1 antibody infliximab was started at 5 mg\/kg\/dose at 9 months of age. She was given three doses at 0, 2, and 6 weeks, respectively. This resulted in significant healing of her fistulas and cessation of fistula output. This improvement was sustained at the time of last follow-up 10 months after treatment.<\/jats:p>","DOI":"10.1136\/bcr.04.2009.1739","type":"journal-article","created":{"date-parts":[[2010,1,14]],"date-time":"2010-01-14T00:13:52Z","timestamp":1263428032000},"page":"bcr0420091739","source":"Crossref","is-referenced-by-count":1,"title":["Anti-TNF\u03b1 antibody infliximab treatment for an infant with fistulising Crohn\u2019s disease"],"prefix":"10.1136","volume":"2010","author":[{"given":"Omar I","family":"Saadah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2010,1,13]]},"reference":[{"key":"2025082704051752000_2010.feb02_1.bcr0420091739.1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200003000-00009"},{"key":"2025082704051752000_2010.feb02_1.bcr0420091739.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199905063401804"},{"key":"2025082704051752000_2010.feb02_1.bcr0420091739.3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3109\/00365529709000184","article-title":"Inflammatory bowel diseases with onset in childhood. 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