{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T15:40:02Z","timestamp":1745595602780,"version":"3.40.4"},"reference-count":12,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Meningomyelocele is one of the commonest neural tube closure defects. A 2-month-old girl presented with meningomyelocele in the lumbosacral region that had been present since birth. She had experienced paraparesis for 1 month. Terminally, she had excessive crying, and died within 1 week of presentation. An autopsy revealed focally infected meningomyelocele with features of Arnold\u2013Chiari II malformation. Associated malformations included polymicrogyria, neuronal heterotopias and neuronal cytomegaly in the brainstem. Cortical malformations may be detected radiologically, thus prompting surgical intervention and reduced mortality. By contrast, the presence of cytomegaly may hinder postsurgical improvement, affecting intellectual outcome in survivors in particular. New genetic revelations also offer a scope for genetic counselling in these conditions.<\/jats:p>","DOI":"10.1136\/bcr.04.2009.1811","type":"journal-article","created":{"date-parts":[[2009,8,19]],"date-time":"2009-08-19T07:32:57Z","timestamp":1250667177000},"page":"bcr0420091811","source":"Crossref","is-referenced-by-count":2,"title":["Meningomyelocele: the tip of the iceberg"],"prefix":"10.1136","volume":"2009","author":[{"given":"Sweety","family":"Shinde","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shikha","family":"Singhal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2009,8,19]]},"reference":[{"key":"2025042508103966000_2009.aug18_1.bcr0420091811.1","unstructured":"Harding B Copp AJ . Malformations. In: Graham DI Lantos PL , eds. Greenfield\u2019s neuropathology. 6th edn. London, UK: Arnold, 1997: 397\u2013536."},{"key":"2025042508103966000_2009.aug18_1.bcr0420091811.2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1227\/00006123-198605000-00008","article-title":"Central nervous system anomalies associated with meningomyelocele, hydrocephalus, and the Arnold-Chiari malformation: reappraisal of theories regarding the pathogenesis of posterior neural tube closure defects","volume":"18","author":"Gilbert","year":"1986","journal-title":"Neurosurgery"},{"key":"2025042508103966000_2009.aug18_1.bcr0420091811.3","first-page":"444","article-title":"Glioneuronal migration and development disorders: histological and immunohistochemical study with a comment on evolution","volume":"50","author":"Pal","year":"2002","journal-title":"Neurol India"},{"key":"2025042508103966000_2009.aug18_1.bcr0420091811.4","unstructured":"Humpreys RP . Spinal dysraphism. In: Wilkins RH Rengachary SR , eds. Neurosurgery. 2nd edn. Columbus, Ohio, USA: McGraw-Hill, 1996: 3453\u201363."},{"key":"2025042508103966000_2009.aug18_1.bcr0420091811.5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1227\/00006123-198308000-00007","article-title":"Experience with surgical decompression of the Arnold-Chiari malformation in young infants with myelomeningocele","volume":"13","author":"Park","year":"1983","journal-title":"Neurosurgery"},{"key":"2025042508103966000_2009.aug18_1.bcr0420091811.6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1212\/01.WNL.0000148647.55705.A3","article-title":"Distinct clinicopathologic subtypes of cortical dysplasia of Taylor","volume":"64","author":"Lawson","year":"2005","journal-title":"Neurology"},{"key":"2025042508103966000_2009.aug18_1.bcr0420091811.7","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21398"},{"key":"2025042508103966000_2009.aug18_1.bcr0420091811.8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2001.042007850.x"},{"key":"2025042508103966000_2009.aug18_1.bcr0420091811.9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1148\/radiology.134.1.7350637","article-title":"Computed tomographic signs of the Chiari II malformation part I: skull and dural partitions","volume":"134","author":"Naidich","year":"1980","journal-title":"Radiology"},{"key":"2025042508103966000_2009.aug18_1.bcr0420091811.10","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1148\/radiology.134.2.7352218","article-title":"Computed tomographic signs of the Chiari II malformation part II: midbrain and cerebellum","volume":"134","author":"Naidich","year":"1980","journal-title":"Radiology"},{"key":"2025042508103966000_2009.aug18_1.bcr0420091811.11","doi-asserted-by":"publisher","DOI":"10.1159\/000120608"},{"key":"2025042508103966000_2009.aug18_1.bcr0420091811.12","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000183747.05269.2d"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.04.2009.1811","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T15:10:49Z","timestamp":1745593849000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.04.2009.1811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":12,"alternative-id":["10.1136\/bcr.04.2009.1811"],"URL":"https:\/\/doi.org\/10.1136\/bcr.04.2009.1811","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2009]]}}}