{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:03:58Z","timestamp":1756425838038,"version":"3.44.0"},"reference-count":19,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy. However, it may rarely associate with eosinophilia. Patients with ALL associated with eosinophilia (ALL\/ Eo) have a grave prognosis and higher incidence of cardiac complications compared to standard lymphoblastic leukaemia. Reports of ALL\/Eo disclosed a few case with cardiac involvement early in the course of leukaemia. Here, the authors report a case of 13-year-old boy who presented with peripheral eosinophilia, chest pain and a large left ventricular mass early in the course of precursor B- cell ALL associated with eosinophilia. He received multi-agent chemotherapy but succumbed to death 25 days after chemotherapy due to a refractory cardio respiratory failure.<\/jats:p>","DOI":"10.1136\/bcr.04.2011.4128","type":"journal-article","created":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T08:20:27Z","timestamp":1326961227000},"page":"bcr0420114128","source":"Crossref","is-referenced-by-count":6,"title":["Cardiac disease in a case of precursor B acute lymphoblastic leukaemia with eosinophilia(ALL\/Eo)"],"prefix":"10.1136","volume":"2012","author":[{"given":"Mehrnaz Asadi","family":"Gharabaghi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pegah","family":"Aghajanzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghazal","family":"Zahedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roghayyeh","family":"Borji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Derakhskan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roya","family":"Sattarzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramezanali","family":"Sharaifian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,1,19]]},"reference":[{"key":"2025082803504540000_2012.jan18_1.bcr0420114128.1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1182\/blood.V42.3.377.377","article-title":"Lymphoblastic leukemia with marked eosinophilia: a report of two cases.","volume":"42","author":"Spitzer","year":"1973","journal-title":"Blood"},{"key":"2025082803504540000_2012.jan18_1.bcr0420114128.2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-209262"},{"key":"2025082803504540000_2012.jan18_1.bcr0420114128.3","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-2-26"},{"key":"2025082803504540000_2012.jan18_1.bcr0420114128.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-008-9360-7"},{"key":"2025082803504540000_2012.jan18_1.bcr0420114128.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2009.01.001"},{"key":"2025082803504540000_2012.jan18_1.bcr0420114128.6","first-page":"2","article-title":"Eosinophilic leukaemias and the idiopathic hypereosinophilic syndrome.","volume":"95","author":"Bain","year":"1996","journal-title":"Br J Haematol"},{"key":"2025082803504540000_2012.jan18_1.bcr0420114128.7","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1182\/blood.V73.8.2081.2081","article-title":"The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene.","volume":"73","author":"Grimaldi","year":"1989","journal-title":"Blood"},{"key":"2025082803504540000_2012.jan18_1.bcr0420114128.8","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1182\/blood.V85.7.1881.bloodjournal8571881","article-title":"A syndrome of lymphoblastic lymphoma, eosinophilia, and myeloid hyperplasia\/malignancy associated with t(8;13)(p11;q11): description of a distinctive clinicopathologic entity.","volume":"85","author":"Inhorn","year":"1995","journal-title":"Blood"},{"key":"2025082803504540000_2012.jan18_1.bcr0420114128.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcpc049009"},{"key":"2025082803504540000_2012.jan18_1.bcr0420114128.10","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.272"},{"key":"2025082803504540000_2012.jan18_1.bcr0420114128.11","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s10024-003-2019-8","article-title":"Acute lymphoblastic leukemia with hypereosinophilia: report of a case with 5q deletion and review of the literature","volume":"6","author":"Wynn","year":"2003","journal-title":"Pediatr Dev Pathol"},{"key":"2025082803504540000_2012.jan18_1.bcr0420114128.12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08103.x"},{"key":"2025082803504540000_2012.jan18_1.bcr0420114128.13","doi-asserted-by":"crossref","first-page":"859","DOI":"10.2310\/JIM.0b013e3181efbc4e","article-title":"Cardiac involvement in patients with hematologic malignancies.","volume":"58","author":"Allegra","year":"2010","journal-title":"J Investig Med"},{"key":"2025082803504540000_2012.jan18_1.bcr0420114128.14","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2010.493572"},{"key":"2025082803504540000_2012.jan18_1.bcr0420114128.15","doi-asserted-by":"crossref","first-page":"241791","DOI":"10.1155\/2010\/241791","article-title":"Acute cardiac failure due to intra-atrial mass caused by zygomycetes in an immunocompromised paediatric patient","volume":"2010","author":"Van de Glind","year":"2010","journal-title":"Case Report Med"},{"key":"2025082803504540000_2012.jan18_1.bcr0420114128.16","first-page":"388","article-title":"Complete regression of massive cardiac involvement associated with acute T cell leukemia following chemotheraphy.","volume":"9","author":"Arat","year":"2008","journal-title":"Eur J Echocardiogr"},{"key":"2025082803504540000_2012.jan18_1.bcr0420114128.17","first-page":"EIM01","article-title":"Catastrophic thromboembolism in a patient with acute lymphoblastic leukemia and hypereosinophilia.","volume":"89","author":"Williams","year":"2004","journal-title":"Haematologica"},{"key":"2025082803504540000_2012.jan18_1.bcr0420114128.18","doi-asserted-by":"publisher","DOI":"10.1080\/1042819021000040161"},{"key":"2025082803504540000_2012.jan18_1.bcr0420114128.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2006.07.018"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.04.2011.4128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:50:55Z","timestamp":1756378255000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.04.2011.4128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,19]]},"references-count":19,"alternative-id":["10.1136\/bcr.04.2011.4128"],"URL":"https:\/\/doi.org\/10.1136\/bcr.04.2011.4128","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2012,1,19]]}}}