{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:14:49Z","timestamp":1792282489053,"version":"4.4.0"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>The authors report the case of a patient with previously undiagnosed acquired haemophilia A who presented to the accident and emergency department with a swollen tongue and difficulty in swallowing. There were no signs of trauma or obvious dental infection. She was admitted onto a high dependency unit for observation. Over the course of the day, the floor of her mouth and neck became increasingly swollen to the extent that she developed breathing difficulties. She was transferred to an intensive care unit, where she was intubated to protect her airway from further compromise. Acquired factor VIII deficiency was diagnosed and appropriate treatment commenced. Despite intervention, her respiratory and cardiovascular functions deteriorated. Following discussions between the medical specialities involved in her care and her family, the decision was made to withdraw support. The patient passed away 96 h after admission.<\/jats:p>","DOI":"10.1136\/bcr.05.2011.4235","type":"journal-article","created":{"date-parts":[[2011,8,5]],"date-time":"2011-08-05T13:54:08Z","timestamp":1312552448000},"page":"bcr0520114235","source":"Crossref","is-referenced-by-count":4,"title":["Acquired factor VIII deficiency presenting as a floor of the mouth swelling"],"prefix":"10.1136","volume":"2011","author":[{"given":"Ahmed","family":"Al-Hilou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TK","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2011,8,5]]},"reference":[{"key":"2025042707571667000_2011.aug04_1.bcr0520114235.1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20390"},{"key":"2025042707571667000_2011.aug04_1.bcr0520114235.2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04731.x"},{"key":"2025042707571667000_2011.aug04_1.bcr0520114235.3","unstructured":"Giangrande P . Acquired hemophilia. In: Schulman S , ed. Treatment of Hemophilia. 38th edition. Montreal: World Federation of Hemophilia 2005."},{"key":"2025042707571667000_2011.aug04_1.bcr0520114235.4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-029850"},{"key":"2025042707571667000_2011.aug04_1.bcr0520114235.5","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1055\/s-0038-1650169","article-title":"A survey of 215 non-hemophilic patients with inhibitors to Factor VIII.","volume":"45","author":"Green","year":"1981","journal-title":"Thromb Haemost"},{"key":"2025042707571667000_2011.aug04_1.bcr0520114235.6","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1055\/s-0038-1665434","article-title":"The treatment of bleeding in acquired haemophilia with recombinant factor VIIa: a multicentre study.","volume":"78","author":"Hay","year":"1997","journal-title":"Thromb Haemost"},{"key":"2025042707571667000_2011.aug04_1.bcr0520114235.7","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2008.001743"},{"key":"2025042707571667000_2011.aug04_1.bcr0520114235.8","first-page":"23","article-title":"Management of acquired hemophilia: a literature review","volume":"2","author":"Holme","year":"2010","journal-title":"J Coagul Disord"},{"key":"2025042707571667000_2011.aug04_1.bcr0520114235.9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2516.2005.01156.x","article-title":"Tailoring haemostatic treatment to patient requirements - an update on monitoring haemostatic response using thrombelastography.","volume":"11 Suppl 1","author":"S\u00c3\u00b8rensen","year":"2005","journal-title":"Haemophilia"},{"key":"2025042707571667000_2011.aug04_1.bcr0520114235.10","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.1365-2516.2003.00856.x","article-title":"Treatment of acquired haemophilia with factor eight inhibitor bypassing activity.","volume":"10","author":"Sallah","year":"2004","journal-title":"Haemophilia"},{"key":"2025042707571667000_2011.aug04_1.bcr0520114235.11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-017988"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.05.2011.4235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T14:57:23Z","timestamp":1745765843000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.05.2011.4235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,5]]},"references-count":11,"alternative-id":["10.1136\/bcr.05.2011.4235"],"URL":"https:\/\/doi.org\/10.1136\/bcr.05.2011.4235","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,5]]}}}