{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T15:10:01Z","timestamp":1745593801783,"version":"3.40.4"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>We present the case of a 57-year-old man who had been on sulphasalazine for 20 years for seropositive non-erosive rheumatoid arthritis and developed a lymphoproliferative disorder, which resolved completely on cessation of sulphasalazine. This is the first report of lymphoproliferative disorder secondary to sulphasalazine. Lymphoproliferative disorders are well recognised with methotrexate and cyclosporine, and recognition of this disorder is critical due to the fact that a number of patients\u2019 symptoms will resolve completely with discontinuation of the drug and will not need further treatment. This case report discusses the literature on lymphoproliferative disorders as well as differential diagnoses like drug rash with eosinophilia and systemic symptoms (DRESS) syndrome.<\/jats:p>","DOI":"10.1136\/bcr.06.2008.0038","type":"journal-article","created":{"date-parts":[[2009,3,17]],"date-time":"2009-03-17T19:41:52Z","timestamp":1237318912000},"page":"bcr0620080038","source":"Crossref","is-referenced-by-count":2,"title":["Lymphoproliferative disorder due to sulphasalazine"],"prefix":"10.1136","volume":"2009","author":[{"given":"Shirish","family":"Dubey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A O","family":"Adebajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2009,3,17]]},"reference":[{"key":"2025042507342410000_2009.mar08_1.bcr0620080038.1","first-page":"270","article-title":"Methotrexate associated lymphoproliferative disorders","volume-title":"Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","volume":"3","author":"Harris","year":"2001"},{"key":"2025042507342410000_2009.mar08_1.bcr0620080038.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(96)00153-4"},{"key":"2025042507342410000_2009.mar08_1.bcr0620080038.3","first-page":"322","article-title":"Lymphoproliferative disorders in rheumatoid arthritis: clinicopathological analysis of 76 cases in relation to methotrexate medication","volume":"34","author":"Hoshida","year":"2007","journal-title":"J Rheumatol"},{"key":"2025042507342410000_2009.mar08_1.bcr0620080038.4","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1200\/JCO.1996.14.6.1943","article-title":"Spontaneous regression of lymphoproliferative disorders in patients treated with methotrexate for rheumatoid arthritis and other rheumatic diseases","volume":"14","author":"Salloum","year":"1996","journal-title":"J Clin Oncol"},{"key":"2025042507342410000_2009.mar08_1.bcr0620080038.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.09.015"},{"key":"2025042507342410000_2009.mar08_1.bcr0620080038.6","doi-asserted-by":"crossref","unstructured":"Kamel OW van de RM Weiss LM . Brief report: reversible lymphomas associated with Epstein-Barr virus occurring during methotrexate therapy for rheumatoid arthritis and dermatomyositis. 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